Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 223585802   4 RNKALRKARGRWIAFLDSDDLWHPSKLEKQLEFMKNNGYSFTYHNFeKIDESSQSLRVLVSGPAIVTRKMM 74
Cdd:COG0463   74 RNAGLAAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSR-LIREGESDLRRLGSRLFNLVRLLT 143

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 223585802   4 RNKALRKARGRWIAFLDSDDLWHPSKLEKQLEFMKNNGYSFTYHNFeKIDESSQSLRVLVSGPAIVTRKMM 74
Cdd:COG0463   74 RNAGLAAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSR-LIREGESDLRRLGSRLFNLVRLLT 143

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223585802   1 ALTRNKALRKARGRWIAFLDSDDLWHPSKLEKQLEFMKNN----------GYSFTYHNFEKI 52
Cdd:cd00761   66 AAARNAGLKAARGEYILFLDADDLLLPDWLERLVAELLADpeadavggpgNLLFRRELLEEI 127

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 223585802   4 RNKALRKARGRWIAFLDSDDLWHPSKLEKQLEFMKNNGYSFTYHNFeKIDESSQSLRVLVSGPAIVTRKMM 74
Cdd:COG0463   74 RNAGLAAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSR-LIREGESDLRRLGSRLFNLVRLLT 143

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223585802   1 ALTRNKALRKARGRWIAFLDSDDLWHPSKLEKQLEFMKNN----------GYSFTYHNFEKI 52
Cdd:cd00761   66 AAARNAGLKAARGEYILFLDADDLLLPDWLERLVAELLADpeadavggpgNLLFRRELLEEI 127

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223585802   3 TRN--KALRKARGRWIAFLDSDDLWHPSKLEKQLE-FMKNNGYSFTYHNFEKIDESSQSLRV-----LVSGPAIVTRKMM 74
Cdd:cd04196   68 ARNfeSLLQAADGDYVFFCDQDDIWLPDKLERLLKaFLKDDKPLLVYSDLELVDENGNPIGEsffeyQKIKPGTSFNNLL 147

                 ....*...
gi 223585802  75 YNYGYPGC 82
Cdd:cd04196  148 FQNVVTGC 155

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 223585802   4 RNKALRKARGRWIAFLDSDDLWHPSKLEKQLEFMKNNGYSFT 45
Cdd:COG1215  103 LNAGLKAARGDIVVFLDADTVLDPDWLRRLVAAFADPGVGAS 144

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.

                         10        20        30
                 ....*....|....*....|....*....|..
gi 223585802   4 RNKALRKARGRWIAFLDSDDLWHPSKLEKQLE 35
Cdd:cd06913   76 KNQAIAQSSGRYLCFLDSDDVMMPQRIRLQYE 107

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 223585802   5 NKALRKARGRWIAFLDSDDLWHPSKLEKQLEFMKNNG 41
Cdd:cd04195   73 NEGLKHCTYDWVARMDTDDISLPDRFEKQLDFIEKNP 109

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 223585802   4 RNKALRKARGRWIAFLDSD-----DLWhpSKLEKQLEFMKNNGYSFTYHNF 49
Cdd:cd02511   63 RNFALELATNDWVLSLDADerltpELA--DEILALLATDDYDGYYVPRRNF 111

colanic acid biosynthesis glycosyltransferase WcaA;

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 223585802   4 RNKALRKARGRWIAFLDSDDLWHPSKLEKQLEFMKN-NGYSFTYHN 48
Cdd:PRK10018  77 RNQAIMLAQGEYITGIDDDDEWTPNRLSVFLAHKQQlVTHAFLYAN 122