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Conserved domains on  [gi|511731743|ref|WP_016380371|]
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MULTISPECIES: HNH endonuclease signature motif containing protein [Lacticaseibacillus]

Protein Classification

HNH endonuclease signature motif containing protein( domain architecture ID 10486785)

HNH endonuclease signature motif containing protein which may catalyze the hydrolysis of DNA

EC:  3.1.-.-
Gene Ontology:  GO:0004519

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 70-117 8.86e-08

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


:

Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 45.81  E-value: 8.86e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 511731743   70 CERCQAKGLYVQADVVDHIVPIRVdwNRRLDESNLQSLCNACHGTKTK 117
Cdd:pfam01844   1 CQYCGRPFHISDALTVDHIIPLSD--GGADDIENLILLCPSCHNKKHN 46
 
Name Accession Description Interval E-value
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 70-117 8.86e-08

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 45.81  E-value: 8.86e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 511731743   70 CERCQAKGLYVQADVVDHIVPIRVdwNRRLDESNLQSLCNACHGTKTK 117
Cdd:pfam01844   1 CQYCGRPFHISDALTVDHIIPLSD--GGADDIENLILLCPSCHNKKHN 46
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
52-115 4.75e-06

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 41.51  E-value: 4.75e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 511731743  52 KSKVWRKLSYSYRL-AHPLCERCQAKGLYVQADVvDHIVPIRVDWnrRLDESNLQSLCNACHGTK 115
Cdd:COG1403    3 PGREWPALRRAVLKrDNGRCQYCGRPFSGDALEV-DHIIPRSRGG--TDTWENLVLLCRRCNRRK 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 63-116 1.13e-04

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 37.84  E-value: 1.13e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 511731743  63 YRLAHPLCERCQAKGlYVQADVVDHIVPIRvdWNRRLDESNLQSLCNACHGTKT 116
Cdd:cd00085    7 LLARDGLCPYCGKPG-GTEGLEVDHIIPLS--DGGNNDLDNLVLLCRKCHRKKH 57
 
Name Accession Description Interval E-value
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 70-117 8.86e-08

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 45.81  E-value: 8.86e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 511731743   70 CERCQAKGLYVQADVVDHIVPIRVdwNRRLDESNLQSLCNACHGTKTK 117
Cdd:pfam01844   1 CQYCGRPFHISDALTVDHIIPLSD--GGADDIENLILLCPSCHNKKHN 46
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
52-115 4.75e-06

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 41.51  E-value: 4.75e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 511731743  52 KSKVWRKLSYSYRL-AHPLCERCQAKGLYVQADVvDHIVPIRVDWnrRLDESNLQSLCNACHGTK 115
Cdd:COG1403    3 PGREWPALRRAVLKrDNGRCQYCGRPFSGDALEV-DHIIPRSRGG--TDTWENLVLLCRRCNRRK 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 63-116 1.13e-04

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 37.84  E-value: 1.13e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 511731743  63 YRLAHPLCERCQAKGlYVQADVVDHIVPIRvdWNRRLDESNLQSLCNACHGTKT 116
Cdd:cd00085    7 LLARDGLCPYCGKPG-GTEGLEVDHIIPLS--DGGNNDLDNLVLLCRKCHRKKH 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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