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Conserved domains on  [gi|654308785|ref|WP_027822260|]
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MULTISPECIES: Gfo/Idh/MocA family oxidoreductase [Lactobacillaceae]

Protein Classification

-; -; Gfo/Idh/MocA family oxidoreductase; Gfo/Idh/MocA family oxidoreductase( domain architecture ID 11430574)

-; -; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to biliverdin reductase A (BLVRA)

CATH:  3.40.50.720
Gene Ontology:  GO:0016491|GO:0016651
PubMed:  26749496

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
8-334 2.86e-53

Predicted dehydrogenase [General function prediction only];


:

Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 177.42  E-value: 2.86e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785   8 KVGIVGIGFIGSDHLHRLTKtVANVDVTAVCDIVPGKAQKELDRQGlqAKTYDDYHDLVNDPNVEVVVCTADNEAHYEIV 87
Cdd:COG0673    5 RVGIIGAGGIGRAHAPALAA-LPGVELVAVADRDPERAEAFAEEYG--VRVYTDYEELLADPDIDAVVIATPNHLHAELA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785  88 MAALKAGKFTFCEKPLALDAKQCMDIINSEKKLGRRmLQVGFMRHYAPEYVQMKKMIDDGVIGKPLMMdQRHYNQTQPE- 166
Cdd:COG0673   82 IAALEAGKHVLCEKPLALTLEEARELVAAAEEAGVV-LMVGFNRRFDPAVRAARELIDSGAIGEIRSV-RARFGHPRPAg 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785 167 --------EYDTAHSIIETAIHEIDLDHWLVNDTYANIRVFSpkQTRHAQNAKIKDPQIVMIETKTGINIINEVFVRCQY 238
Cdd:COG0673  160 padwrfdpELAGGGALLDLGIHDIDLARWLLGSEPESVSATG--GRLVPDRVEVDDTAAATLRFANGAVATLEASWVAPG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785 239 G-YDIKCDVIGEEGVLelptvpqvatrlnaqystailtdwkarfesaydiefrdFIGHVSKNESPVgPSSWDGYIAAVTA 317
Cdd:COG0673  238 GeRDERLEVYGTKGTL--------------------------------------FVDAIRGGEPPP-VSLEDGLRALELA 278

                        330
                 ....*....|....*..
gi 654308785 318 DAALKSlAEDGAKQDLD 334
Cdd:COG0673  279 EAAYES-ARTGRRVELP 294
 
Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
8-334 2.86e-53

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 177.42  E-value: 2.86e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785   8 KVGIVGIGFIGSDHLHRLTKtVANVDVTAVCDIVPGKAQKELDRQGlqAKTYDDYHDLVNDPNVEVVVCTADNEAHYEIV 87
Cdd:COG0673    5 RVGIIGAGGIGRAHAPALAA-LPGVELVAVADRDPERAEAFAEEYG--VRVYTDYEELLADPDIDAVVIATPNHLHAELA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785  88 MAALKAGKFTFCEKPLALDAKQCMDIINSEKKLGRRmLQVGFMRHYAPEYVQMKKMIDDGVIGKPLMMdQRHYNQTQPE- 166
Cdd:COG0673   82 IAALEAGKHVLCEKPLALTLEEARELVAAAEEAGVV-LMVGFNRRFDPAVRAARELIDSGAIGEIRSV-RARFGHPRPAg 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785 167 --------EYDTAHSIIETAIHEIDLDHWLVNDTYANIRVFSpkQTRHAQNAKIKDPQIVMIETKTGINIINEVFVRCQY 238
Cdd:COG0673  160 padwrfdpELAGGGALLDLGIHDIDLARWLLGSEPESVSATG--GRLVPDRVEVDDTAAATLRFANGAVATLEASWVAPG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785 239 G-YDIKCDVIGEEGVLelptvpqvatrlnaqystailtdwkarfesaydiefrdFIGHVSKNESPVgPSSWDGYIAAVTA 317
Cdd:COG0673  238 GeRDERLEVYGTKGTL--------------------------------------FVDAIRGGEPPP-VSLEDGLRALELA 278

                        330
                 ....*....|....*..
gi 654308785 318 DAALKSlAEDGAKQDLD 334
Cdd:COG0673  279 EAAYES-ARTGRRVELP 294
GFO_IDH_MocA pfam01408
Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. ...
 8-129 5.84e-26

Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 426248 [Multi-domain]  Cd Length: 120  Bit Score: 100.36  E-value: 5.84e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785    8 KVGIVGIGFIGSDHLHRLTKTVANVDVTAVCDIVPGKAQKEldRQGLQAKTYDDYHDLVNDPNVEVVVCTADNEAHYEIV 87
Cdd:pfam01408   2 RVGIIGAGKIGSKHARALNASQPGAELVAILDPNSERAEAV--AESFGVEVYSDLEELLNDPEIDAVIVATPNGLHYDLA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 654308785   88 MAALKAGKFTFCEKPLALDAKQCMDIINSEKKLGRRmLQVGF 129
Cdd:pfam01408  80 IAALEAGKHVLCEKPLATTVEEAKELVELAKKKGVR-VSVGF 120
PRK11579 PRK11579
putative oxidoreductase; Provisional
 1-166 1.40e-09

putative oxidoreductase; Provisional


Pssm-ID: 183212 [Multi-domain]  Cd Length: 346  Bit Score: 58.58  E-value: 1.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785   1 MAEAhvTKVGIVGIGFiGSDHLHR-LTKTVANVDVTAVCDIVPGKAQKelDRQGLQAKTydDYHDLVNDPNVEVVVCTAD 79
Cdd:PRK11579   1 MSDK--IRVGLIGYGY-ASKTFHApLIAGTPGLELAAVSSSDATKVKA--DWPTVTVVS--EPQHLFNDPNIDLIVIPTP 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785  80 NEAHYEIVMAALKAGKFTFCEKPLALDAKQCMDIINSEKKLGrRMLQVGFMRHYAPEYVQMKKMIDDGVIGKPLMMDQrH 159
Cdd:PRK11579  74 NDTHFPLAKAALEAGKHVVVDKPFTVTLSQARELDALAKSAG-RVLSVFHNRRWDSDFLTLKALLAEGVLGEVAYFES-H 151


                 ....*..
gi 654308785 160 YNQTQPE 166
Cdd:PRK11579 152 FDRFRPQ 158
 
Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
8-334 2.86e-53

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 177.42  E-value: 2.86e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785   8 KVGIVGIGFIGSDHLHRLTKtVANVDVTAVCDIVPGKAQKELDRQGlqAKTYDDYHDLVNDPNVEVVVCTADNEAHYEIV 87
Cdd:COG0673    5 RVGIIGAGGIGRAHAPALAA-LPGVELVAVADRDPERAEAFAEEYG--VRVYTDYEELLADPDIDAVVIATPNHLHAELA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785  88 MAALKAGKFTFCEKPLALDAKQCMDIINSEKKLGRRmLQVGFMRHYAPEYVQMKKMIDDGVIGKPLMMdQRHYNQTQPE- 166
Cdd:COG0673   82 IAALEAGKHVLCEKPLALTLEEARELVAAAEEAGVV-LMVGFNRRFDPAVRAARELIDSGAIGEIRSV-RARFGHPRPAg 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785 167 --------EYDTAHSIIETAIHEIDLDHWLVNDTYANIRVFSpkQTRHAQNAKIKDPQIVMIETKTGINIINEVFVRCQY 238
Cdd:COG0673  160 padwrfdpELAGGGALLDLGIHDIDLARWLLGSEPESVSATG--GRLVPDRVEVDDTAAATLRFANGAVATLEASWVAPG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785 239 G-YDIKCDVIGEEGVLelptvpqvatrlnaqystailtdwkarfesaydiefrdFIGHVSKNESPVgPSSWDGYIAAVTA 317
Cdd:COG0673  238 GeRDERLEVYGTKGTL--------------------------------------FVDAIRGGEPPP-VSLEDGLRALELA 278

                        330
                 ....*....|....*..
gi 654308785 318 DAALKSlAEDGAKQDLD 334
Cdd:COG0673  279 EAAYES-ARTGRRVELP 294
GFO_IDH_MocA pfam01408
Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. ...
 8-129 5.84e-26

Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 426248 [Multi-domain]  Cd Length: 120  Bit Score: 100.36  E-value: 5.84e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785    8 KVGIVGIGFIGSDHLHRLTKTVANVDVTAVCDIVPGKAQKEldRQGLQAKTYDDYHDLVNDPNVEVVVCTADNEAHYEIV 87
Cdd:pfam01408   2 RVGIIGAGKIGSKHARALNASQPGAELVAILDPNSERAEAV--AESFGVEVYSDLEELLNDPEIDAVIVATPNGLHYDLA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 654308785   88 MAALKAGKFTFCEKPLALDAKQCMDIINSEKKLGRRmLQVGF 129
Cdd:pfam01408  80 IAALEAGKHVLCEKPLATTVEEAKELVELAKKKGVR-VSVGF 120
GFO_IDH_MocA_C pfam02894
Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or ...
 141-327 2.85e-12

Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 427044  Cd Length: 203  Bit Score: 65.13  E-value: 2.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785  141 KKMIDDGVIGKPLMMDQRHYNQTQPEEYD---------TAHSIIETAIHEIDLDHWLVNDTYANIRVFSPkqtrhaqnak 211
Cdd:pfam02894   1 KELIENGVLGEVVMVTVHTRDPFRPPQEFkrwrvdpekSGGALYDLGIHTIDLLIYLFGEPPSVVAVYAS---------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785  212 iKDPQIVMIETKTGINI---INEVFVRCQYGYDIKcdVIGEEGVLELPTVP-------------QVATRLNAQYSTAILT 275
Cdd:pfam02894  71 -EDTAFATLEFKNGAVGtleTSGGSIVEANGHRIS--IHGTKGSIELDGIDdgllsvtvvgepgWATDDPMVRKGGDEVP 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 654308785  276 DWKARFESAYDIEFRDFIGHVsKNESPVGPSSWDGYIAAVTADAALKSLAED 327
Cdd:pfam02894 148 EFLGSFAGGYLLEYDAFLEAV-RGGKVVLVDAEDGLYALAVIEAAYESAEEG 198
PRK11579 PRK11579
putative oxidoreductase; Provisional
 1-166 1.40e-09

putative oxidoreductase; Provisional


Pssm-ID: 183212 [Multi-domain]  Cd Length: 346  Bit Score: 58.58  E-value: 1.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785   1 MAEAhvTKVGIVGIGFiGSDHLHR-LTKTVANVDVTAVCDIVPGKAQKelDRQGLQAKTydDYHDLVNDPNVEVVVCTAD 79
Cdd:PRK11579   1 MSDK--IRVGLIGYGY-ASKTFHApLIAGTPGLELAAVSSSDATKVKA--DWPTVTVVS--EPQHLFNDPNIDLIVIPTP 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785  80 NEAHYEIVMAALKAGKFTFCEKPLALDAKQCMDIINSEKKLGrRMLQVGFMRHYAPEYVQMKKMIDDGVIGKPLMMDQrH 159
Cdd:PRK11579  74 NDTHFPLAKAALEAGKHVVVDKPFTVTLSQARELDALAKSAG-RVLSVFHNRRWDSDFLTLKALLAEGVLGEVAYFES-H 151


                 ....*..
gi 654308785 160 YNQTQPE 166
Cdd:PRK11579 152 FDRFRPQ 158
PRK13304 PRK13304
aspartate dehydrogenase;
8-95 7.91e-06

aspartate dehydrogenase;


Pssm-ID: 237343 [Multi-domain]  Cd Length: 265  Bit Score: 46.91  E-value: 7.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785   8 KVGIVGIGFIGSdhlhRLTKTVA----NVDVTAVCDIVPGKAQKeldrqgLQAKTYDDYHDLVND--PNVEVVVCTADNE 81
Cdd:PRK13304   3 KIGIVGCGAIAS----LITKAILsgriNAELYAFYDRNLEKAEN------LASKTGAKACLSIDElvEDVDLVVECASVN 72

                         90
                 ....*....|....
gi 654308785  82 AHYEIVMAALKAGK 95
Cdd:PRK13304  73 AVEEVVPKSLENGK 86
COG4091 COG4091
Predicted homoserine dehydrogenase, contains C-terminal SAF domain [Amino acid transport and ...
 8-95 2.21e-05

Predicted homoserine dehydrogenase, contains C-terminal SAF domain [Amino acid transport and metabolism];


Pssm-ID: 443267 [Multi-domain]  Cd Length: 429  Bit Score: 45.91  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785   8 KVGIVGIGFIGSDHLHRLTKtVANVDVTAVCDIVPGKAQKELDRQGLQA-------------------KTY--DDYHDLV 66
Cdd:COG4091   17 RVGLIGAGQMGRGLLAQIRR-MPGMEVVAIADRNPERARAALREAGIPEedirvvdtaaeadaaiaagKTVvtDDAELLI 95

                         90       100       110
                 ....*....|....*....|....*....|
gi 654308785  67 NDPNVEVVV-CTADNEAHYEIVMAALKAGK 95
Cdd:COG4091   96 AADGIDVVVeATGVPEAGARHALAAIEAGK 125
PRK10206 PRK10206
putative oxidoreductase; Provisional
 61-166 2.22e-05

putative oxidoreductase; Provisional


Pssm-ID: 182305 [Multi-domain]  Cd Length: 344  Bit Score: 45.58  E-value: 2.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785  61 DYHDLVNDPNVE-VVVCT-ADneAHYEIVMAALKAGKFTFCEKPLA---LDAKQCMDIINSeKKLGRRMLQvgfMRHYAP 135
Cdd:PRK10206  55 DLDEVLNDPDVKlVVVCThAD--SHFEYAKRALEAGKNVLVEKPFTptlAEAKELFALAKS-KGLTVTPYQ---NRRFDS 128

                         90       100       110
                 ....*....|....*....|....*....|.
gi 654308785 136 EYVQMKKMIDDGVIGKPLMMDQrHYNQTQPE 166
Cdd:PRK10206 129 CFLTAKKAIESGKLGEIVEVES-HFDYYRPV 158
PRK06349 PRK06349
homoserine dehydrogenase; Provisional
 8-95 5.64e-04

homoserine dehydrogenase; Provisional


Pssm-ID: 235783 [Multi-domain]  Cd Length: 426  Bit Score: 41.60  E-value: 5.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785   8 KVGIVGIGFIGS-------DHLHRLTKTV-ANVDVTAVCDIVPGKAQkelDRQGLQAKTYDDYHDLVNDPNVEVVVctad 79
Cdd:PRK06349   5 KVGLLGLGTVGSgvvrileENAEEIAARAgRPIEIKKVAVRDLEKDR---GVDLPGILLTTDPEELVNDPDIDIVV---- 77

                         90       100
                 ....*....|....*....|..
gi 654308785  80 nE------AHYEIVMAALKAGK 95
Cdd:PRK06349  78 -ElmggiePARELILKALEAGK 98
DUF6725 pfam20486
Family of unknown function (DUF6725); This family of proteins is functionally uncharacterized. ...
 288-320 1.60e-03

Family of unknown function (DUF6725); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.


Pssm-ID: 466635  Cd Length: 83  Bit Score: 36.88  E-value: 1.60e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 654308785  288 EFRDFIGHVsknespvgpSSWDGYIAAVTADAA 320
Cdd:pfam20486  29 KYRDYVGHV---------RSWDGRTLELTRDAA 52
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 7-94 2.82e-03

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 36.80  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785    7 TKVGIVGIGFIGSDHLHRLTKTVANVDVTAVCDIVPGKAQKELdrQGLqaKTYDDYHDLVNDPNVEVVVCTADNEAHYEI 86
Cdd:pfam02629   4 TKVIVIGAGGLGIQGLNYHFIQMLGYGIKMVFGVNPGKGGTEI--LGI--PVYNSVDELEEKTGVDVAVITVPAPFAQEA 79


                  ....*...
gi 654308785   87 VMAALKAG 94
Cdd:pfam02629  80 IDELVDAG 87
NAD_binding_3 pfam03447
Homoserine dehydrogenase, NAD binding domain; This domain adopts a Rossmann NAD binding fold. ...
 13-95 6.86e-03

Homoserine dehydrogenase, NAD binding domain; This domain adopts a Rossmann NAD binding fold. The C-terminal domain of homoserine dehydrogenase contributes a single helix to this structural domain, which is not included in the Pfam model.


Pssm-ID: 281446 [Multi-domain]  Cd Length: 116  Bit Score: 36.13  E-value: 6.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654308785   13 GIGFIGSDHLHRLT--KTVANVDVTAVCDIVPGKAQKELDRQGlqAKTYDDYHDLVNDPNVEVVV-CTADNEAHyEIVMA 89
Cdd:pfam03447   1 GCGAIGSGVLEQLLrqQSEIPLELVAVADRDLLSKDPLALLPD--EPLTLDLDDLIAHPDPDVVVeCASSEAVA-ELVLD 77


                  ....*.
gi 654308785   90 ALKAGK 95
Cdd:pfam03447  78 ALKAGK 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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