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Conserved domains on  [gi|1119260087|ref|WP_072241855|]
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MULTISPECIES: small membrane protein YmiC [Lelliottia]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
membrane_YmiC super family cl49464
small membrane protein YmiC; YmiC is an uncharacterized predicted protein about 32 amino acids ...
4-33 3.63e-08

small membrane protein YmiC; YmiC is an uncharacterized predicted protein about 32 amino acids long, hypothesized to be real and a membrane protein based on conservation across multiple gammaproteobacteria with constant length and constant hydrophobic character suggesting insertion into membrane. Expression was verified for a construct with an added C-terminal epitope. Homologs tend to show a pattern of conservative amino acid substitutions. Thus, comparative genomics also suggests YmiC is a real protein. An usual feature is three perfectly invariant Trp residues, and a highly conserved fourth, in a stretch of 19 residues.


The actual alignment was detected with superfamily member NF041484:

Pssm-ID: 469372  Cd Length: 30  Bit Score: 42.32  E-value: 3.63e-08
                         10        20        30
                 ....*....|....*....|....*....|
gi 1119260087  4 TLQNVKYWSWMGAFTVSILFWCQLIWLALN 33
Cdd:NF041484   1 NHSNMKYWSWMGAFSVSILFWAQLIWLLLN 30
 
Name Accession Description Interval E-value
membrane_YmiC NF041484
small membrane protein YmiC; YmiC is an uncharacterized predicted protein about 32 amino acids ...
4-33 3.63e-08

small membrane protein YmiC; YmiC is an uncharacterized predicted protein about 32 amino acids long, hypothesized to be real and a membrane protein based on conservation across multiple gammaproteobacteria with constant length and constant hydrophobic character suggesting insertion into membrane. Expression was verified for a construct with an added C-terminal epitope. Homologs tend to show a pattern of conservative amino acid substitutions. Thus, comparative genomics also suggests YmiC is a real protein. An usual feature is three perfectly invariant Trp residues, and a highly conserved fourth, in a stretch of 19 residues.


Pssm-ID: 469372  Cd Length: 30  Bit Score: 42.32  E-value: 3.63e-08
                         10        20        30
                 ....*....|....*....|....*....|
gi 1119260087  4 TLQNVKYWSWMGAFTVSILFWCQLIWLALN 33
Cdd:NF041484   1 NHSNMKYWSWMGAFSVSILFWAQLIWLLLN 30
 
Name Accession Description Interval E-value
membrane_YmiC NF041484
small membrane protein YmiC; YmiC is an uncharacterized predicted protein about 32 amino acids ...
4-33 3.63e-08

small membrane protein YmiC; YmiC is an uncharacterized predicted protein about 32 amino acids long, hypothesized to be real and a membrane protein based on conservation across multiple gammaproteobacteria with constant length and constant hydrophobic character suggesting insertion into membrane. Expression was verified for a construct with an added C-terminal epitope. Homologs tend to show a pattern of conservative amino acid substitutions. Thus, comparative genomics also suggests YmiC is a real protein. An usual feature is three perfectly invariant Trp residues, and a highly conserved fourth, in a stretch of 19 residues.


Pssm-ID: 469372  Cd Length: 30  Bit Score: 42.32  E-value: 3.63e-08
                         10        20        30
                 ....*....|....*....|....*....|
gi 1119260087  4 TLQNVKYWSWMGAFTVSILFWCQLIWLALN 33
Cdd:NF041484   1 NHSNMKYWSWMGAFSVSILFWAQLIWLLLN 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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