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Conserved domains on  [gi|1861249674|ref|WP_176087187|]
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TolC family protein, partial [Burkholderia vietnamiensis]

Protein Classification

efflux transporter outer membrane subunit( domain architecture ID 1002616)

efflux transporter outer membrane subunit similar to Pseudomonas aeruginosa outer membrane protein OprJ, a channel-forming component of a multidrug resistance efflux pump

CATH:  2.20.200.10|1.20.1600.10
Gene Ontology:  GO:0015562|GO:0055085
PubMed:  10092468
SCOP:  4003096
TCDB:  1.B.17

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09837 super family cl32423
Cu(I)/Ag(I) efflux RND transporter outer membrane protein;
1-121 3.63e-40

Cu(I)/Ag(I) efflux RND transporter outer membrane protein;


The actual alignment was detected with superfamily member PRK09837:

Pssm-ID: 182103 [Multi-domain]  Cd Length: 461  Bit Score: 139.24  E-value: 3.63e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861249674   1 LLTRRPDVMQAEQTLLAANANIGAARAAFFPRISLTAAFGTASPTLGGLFKAGTAAWSFAPQLTMPIFEGGQNIANLNLA 80
Cdd:PRK09837  277 ILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGLSTSSSDLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDLA 356

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1861249674  81 NVQKRIEIANYEKAIQSAFREVSDGLAACGTYDLQIAALER 121
Cdd:PRK09837  357 EIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQR 397
 
Name Accession Description Interval E-value
PRK09837 PRK09837
Cu(I)/Ag(I) efflux RND transporter outer membrane protein;
1-121 3.63e-40

Cu(I)/Ag(I) efflux RND transporter outer membrane protein;


Pssm-ID: 182103 [Multi-domain]  Cd Length: 461  Bit Score: 139.24  E-value: 3.63e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861249674   1 LLTRRPDVMQAEQTLLAANANIGAARAAFFPRISLTAAFGTASPTLGGLFKAGTAAWSFAPQLTMPIFEGGQNIANLNLA 80
Cdd:PRK09837  277 ILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGLSTSSSDLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDLA 356

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1861249674  81 NVQKRIEIANYEKAIQSAFREVSDGLAACGTYDLQIAALER 121
Cdd:PRK09837  357 EIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQR 397
outer_NodT TIGR01845
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ...
 1-131 1.81e-28

efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]


Pssm-ID: 273830 [Multi-domain]  Cd Length: 460  Bit Score: 107.50  E-value: 1.81e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861249674   1 LLTRRPDVMQAEQTLLAANANIGAARAAFFPRISLTAAFGTASPTLGGLFKAGTAAWSFAPQLTMPIFEGGQNIANLNLA 80
Cdd:TIGR01845 279 LLRRRPDIRAAERRLAAANAQIGVAKAAFFPSITLSASIGLSASQLSRLFDGGSRFWSIGPALALPIFDGGSLRAALDSA 358

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1861249674  81 NVQKRIEIANYEKAIQSAFREVSDGLAACGTYDLQIAALERNEHAQQRRFD 131
Cdd:TIGR01845 359 KATYDAAVAQYRQTVLTAFQEVADALVALQALARRLDAQRQAVEQAQEALS 409
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
1-131 3.60e-25

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 97.80  E-value: 3.60e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861249674   1 LLTRRPDVMQAEQTLLAANANIGAARAAFFPRISLTAAFGTASPTlgGLFKAGTAAWSFAPQLTMPIFEGGQNIANLNLA 80
Cdd:COG1538   186 ALERRPDLRAAEAQLEAAEAEIGVARAAFLPSLSLSASYGYSSSD--DLFSGGSDTWSVGLSLSLPLFDGGRNRARVRAA 263

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1861249674  81 NVQKRIEIANYEKAIQSAFREVSDGLAACGTYDLQIAALERNEHAQQRRFD 131
Cdd:COG1538   264 KAQLEQAEAQYEQTVLQALQEVEDALAALRAAREQLEALEEALEAAEEALE 314
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
 2-103 9.84e-12

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 59.07  E-value: 9.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861249674   2 LTRRPDVMQAEQTLLAANANIGAARAAFFPRISLTAAFGTASPTlGGLFKAGTAAWSFAPQLTMPIFEGGQNIANLNLAN 81
Cdd:pfam02321   4 LENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYGYNSNN-SESGGDDPGTGEVGLGLSQPLFDGGKRRARVKAAK 82

                          90       100
                  ....*....|....*....|..
gi 1861249674  82 VQKRIEIANYEKAIQSAFREVS 103
Cdd:pfam02321  83 AQVEAAEAQLEQARQQLRLEVA 104
 
Name Accession Description Interval E-value
PRK09837 PRK09837
Cu(I)/Ag(I) efflux RND transporter outer membrane protein;
1-121 3.63e-40

Cu(I)/Ag(I) efflux RND transporter outer membrane protein;


Pssm-ID: 182103 [Multi-domain]  Cd Length: 461  Bit Score: 139.24  E-value: 3.63e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861249674   1 LLTRRPDVMQAEQTLLAANANIGAARAAFFPRISLTAAFGTASPTLGGLFKAGTAAWSFAPQLTMPIFEGGQNIANLNLA 80
Cdd:PRK09837  277 ILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGLSTSSSDLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDLA 356

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1861249674  81 NVQKRIEIANYEKAIQSAFREVSDGLAACGTYDLQIAALER 121
Cdd:PRK09837  357 EIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQR 397
outer_NodT TIGR01845
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ...
 1-131 1.81e-28

efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]


Pssm-ID: 273830 [Multi-domain]  Cd Length: 460  Bit Score: 107.50  E-value: 1.81e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861249674   1 LLTRRPDVMQAEQTLLAANANIGAARAAFFPRISLTAAFGTASPTLGGLFKAGTAAWSFAPQLTMPIFEGGQNIANLNLA 80
Cdd:TIGR01845 279 LLRRRPDIRAAERRLAAANAQIGVAKAAFFPSITLSASIGLSASQLSRLFDGGSRFWSIGPALALPIFDGGSLRAALDSA 358

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1861249674  81 NVQKRIEIANYEKAIQSAFREVSDGLAACGTYDLQIAALERNEHAQQRRFD 131
Cdd:TIGR01845 359 KATYDAAVAQYRQTVLTAFQEVADALVALQALARRLDAQRQAVEQAQEALS 409
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
1-131 3.60e-25

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 97.80  E-value: 3.60e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861249674   1 LLTRRPDVMQAEQTLLAANANIGAARAAFFPRISLTAAFGTASPTlgGLFKAGTAAWSFAPQLTMPIFEGGQNIANLNLA 80
Cdd:COG1538   186 ALERRPDLRAAEAQLEAAEAEIGVARAAFLPSLSLSASYGYSSSD--DLFSGGSDTWSVGLSLSLPLFDGGRNRARVRAA 263

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1861249674  81 NVQKRIEIANYEKAIQSAFREVSDGLAACGTYDLQIAALERNEHAQQRRFD 131
Cdd:COG1538   264 KAQLEQAEAQYEQTVLQALQEVEDALAALRAAREQLEALEEALEAAEEALE 314
PRK11459 PRK11459
multidrug resistance outer membrane protein MdtQ; Provisional
 1-131 1.87e-15

multidrug resistance outer membrane protein MdtQ; Provisional


Pssm-ID: 183143 [Multi-domain]  Cd Length: 478  Bit Score: 71.13  E-value: 1.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861249674   1 LLTRRPDVMQAEQTLLAANANIGAARAAFFPRISLTAAFGTASPTLGGLFKAGTAAWSFAPQLTMPIFEGGQNIANLNLA 80
Cdd:PRK11459  294 LLARRADLQAAHWYIESSLSTIDAAKAAFYPDINLMAFLQQDALHLSDLFRHSAQQMGVTAGLTLPIFDSGRLNANLDIA 373

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1861249674  81 NVQKRIEIANYEKAIQSAFREVSDGLAACGTYdlqiaaLERNEHAQQRRFD 131
Cdd:PRK11459  374 KAQSNLSIASYNKAVVDAVNDVARAASQVETL------AEKNQHQQQIERD 418
PRK09915 PRK09915
MdtP family multidrug efflux transporter outer membrane subunit;
1-103 6.50e-14

MdtP family multidrug efflux transporter outer membrane subunit;


Pssm-ID: 182142 [Multi-domain]  Cd Length: 488  Bit Score: 66.83  E-value: 6.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861249674   1 LLTRRPDVMQAEQTLLAANANIGAARAAFFPRISLTAAFGTASPTLGGLFKAGTAAWSFAPQLTMPIFEGGQNIANLNLA 80
Cdd:PRK09915  297 LLARRPDLQAMRWYVQASLDQVDSARALFYPSFDIKAFFGLDAIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGT 376

                          90       100
                  ....*....|....*....|...
gi 1861249674  81 NVQKRIEIANYEKAIQSAFREVS 103
Cdd:PRK09915  377 RAASNMMIERYNQSVLNAVRDVA 399
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
 2-103 9.84e-12

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 59.07  E-value: 9.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861249674   2 LTRRPDVMQAEQTLLAANANIGAARAAFFPRISLTAAFGTASPTlGGLFKAGTAAWSFAPQLTMPIFEGGQNIANLNLAN 81
Cdd:pfam02321   4 LENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYGYNSNN-SESGGDDPGTGEVGLGLSQPLFDGGKRRARVKAAK 82

                          90       100
                  ....*....|....*....|..
gi 1861249674  82 VQKRIEIANYEKAIQSAFREVS 103
Cdd:pfam02321  83 AQVEAAEAQLEQARQQLRLEVA 104
type_I_sec_TolC TIGR01844
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane ...
 2-131 6.17e-07

type I secretion outer membrane protein, TolC family; Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins]


Pssm-ID: 273829 [Multi-domain]  Cd Length: 415  Bit Score: 46.98  E-value: 6.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861249674   2 LTRRPDVMQAEQTLLAANANIGAARAAFFPRISLTAAFGTASPTLGGLFKAGTAAWSFAPQLTMPIFEGGQNIANLNLAN 81
Cdd:TIGR01844 221 EASNPLLLAAQAAVDAARYQVEQARAGHLPTLSLTASTGNSDTSSGGSGNSDSDTYSVGLNVSIPLYQGGATSAQVRQAA 300

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1861249674  82 VQKRIEIANYEKAIQSAFREVSDGLAACGTYDLQIAALERNEHAQQRRFD 131
Cdd:TIGR01844 301 HQLNQSRSTLESQKRTVRQQVRNAWSNLNAAAASVQAYEQQVASAQKALD 350
type_I_sec_TolC TIGR01844
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane ...
 2-131 1.40e-06

type I secretion outer membrane protein, TolC family; Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins]


Pssm-ID: 273829 [Multi-domain]  Cd Length: 415  Bit Score: 45.83  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861249674   2 LTRRPDVMQAEQTLLAANANIGAARAAFFPRISLTAAFGTA--SPTLGGLFKAGTAAWSFAPQLTMPIFEGGQNIANLNL 79
Cdd:TIGR01844  13 LANNPELRAARAQRDAGEEQVAQARAALLPQLGLTANYGYSntYPTESRGRNTDLNSGSSTLTLSQPLFDGGSTWNAVRA 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1861249674  80 ANVQKRIEIANYEKAIQSAFREVSDGLAACGTYDLQIAALERNEHAQQRRFD 131
Cdd:TIGR01844  93 AEAAALAARETLRATAQDLILRTAEAYMEVLRAQEILALAEANLAALKEQLD 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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