|
Name |
Accession |
Description |
Interval |
E-value |
| recQ |
TIGR01389 |
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 ... |
7-586 |
0e+00 |
|
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273594 [Multi-domain] Cd Length: 591 Bit Score: 783.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 7 AQQVLKTTFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALLFQGITVVVSPLISLMKDQVDALNDNGIAA 86
Cdd:TIGR01389 1 AQQVLKRTFGYDDFRPGQEEIISHVLDGRDVLVVMPTGGGKSLCYQVPALLLKGLTVVISPLISLMKDQVDQLRAAGVAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 87 TFINSSLDFQAINERLQELRAGDYTLLYVAPERLDSEYFIQALGRLPIQLLAIDEAHCISQWGHDFRPSYLALSTAIEQL 166
Cdd:TIGR01389 81 AYLNSTLSAKEQQDIEKALVNGELKLLYVAPERLEQDYFLNMLQRIPIALVAVDEAHCVSQWGHDFRPEYQRLGSLAERF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 167 PTHPqVLALTATATEQVAADICGRLAIDPQHEVNTGFARDNLDLTVVKDQDTDRYILDYLKVNHGEAGIIYASTRKEVMR 246
Cdd:TIGR01389 161 PQVP-RIALTATADAETRQDIRELLRLADANEFITSFDRPNLRFSVVKKNNKQKFLLDYLKKHRGQSGIIYASSRKKVEE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 247 LTSLLQKHHINATPYHAGLDPEVRRHNQEDFLYDRVDVMVATNAFGMGIDKSNVRFVIHAQVPGTLEAYYQEAGRAGRDG 326
Cdd:TIGR01389 240 LAERLESQGISALAYHAGLSNKVRAENQEDFLYDDVKVMVATNAFGMGIDKPNVRFVIHYDMPGNLESYYQEAGRAGRDG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 327 LPSEAILLFRPNDIQLQHYFIDESEMDTEHRHLAYRKLQVMTRYANTQGCLQQFILKYFGEDS-EPCGRCSNCTDKREAK 405
Cdd:TIGR01389 320 LPAEAILLYSPADIALLKRRIEQSEADDDYKQIEREKLRAMIAYCETQTCRRAYILRYFGENEvEPCGNCDNCLDPPKSY 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 406 DITTAAQQVLSCVVRLHSRFGKGVVAQVLTGANNQRIRESHLEGLSTYGLMSGQRQKAVVELIDFLTASGYL-------Q 478
Cdd:TIGR01389 400 DATVEAQKALSCVYRMGQRFGVGYIIEVLRGSKNDKILQKGHDQLSTYGIGKDYTQKEWRSLIDQLIAEGLLtendeiyI 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 479 AVGGQYPTLTVTASGVDVLKGNTTVRRKTAQTVQQ--TVPENSALFEQLRTLRRQLAEEQGVPPFVIFSDKTLHSMCEVM 556
Cdd:TIGR01389 480 GLQLTEAARKVLKNEVEVLLRPFKVVAKEKTRVQKnlSVGVDNALFEALRELRKEQADEQNVPPYVIFSDSTLREMAEKR 559
|
570 580 590
....*....|....*....|....*....|
gi 2440800153 557 PEDDQAFLTVKGVGASKLEKYGETFMATIR 586
Cdd:TIGR01389 560 PATLNALLKIKGVGQNKLDRYGEAFLEVIR 589
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
3-473 |
0e+00 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 757.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 3 DLAAAQQVLKTTFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALLFQGITVVVSPLISLMKDQVDALNDN 82
Cdd:COG0514 1 LRDDALEVLKRVFGYDSFRPGQEEIIEAVLAGRDALVVMPTGGGKSLCYQLPALLLPGLTLVVSPLIALMKDQVDALRAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 83 GIAATFINSSLDFQAINERLQELRAGDYTLLYVAPERLDSEYFIQALGRLPIQLLAIDEAHCISQWGHDFRPSYLALSTA 162
Cdd:COG0514 81 GIRAAFLNSSLSAEERREVLRALRAGELKLLYVAPERLLNPRFLELLRRLKISLFAIDEAHCISQWGHDFRPDYRRLGEL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 163 IEQLPtHPQVLALTATATEQVAADICGRLAIDPQHEVNTGFARDNLDLTVVK--DQDTDRYILDYLKVNHGEAGIIYAST 240
Cdd:COG0514 161 RERLP-NVPVLALTATATPRVRADIAEQLGLEDPRVFVGSFDRPNLRLEVVPkpPDDKLAQLLDFLKEHPGGSGIVYCLS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 241 RKEVMRLTSLLQKHHINATPYHAGLDPEVRRHNQEDFLYDRVDVMVATNAFGMGIDKSNVRFVIHAQVPGTLEAYYQEAG 320
Cdd:COG0514 240 RKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIAFGMGIDKPDVRFVIHYDLPKSIEAYYQEIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 321 RAGRDGLPSEAILLFRPNDIQLQHYFIDESEMDTEHRHLAYRKLQVMTRYANTQGCLQQFILKYFGED-SEPCGRCSNCT 399
Cdd:COG0514 320 RAGRDGLPAEALLLYGPEDVAIQRFFIEQSPPDEERKRVERAKLDAMLAYAETTGCRRQFLLRYFGEElAEPCGNCDNCL 399
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2440800153 400 DKREAKDITTAAQQVLSCVVRLHSRFGKGVVAQVLTGANNQRIRESHLEGLSTYGLMSGQRQKAVVELIDFLTA 473
Cdd:COG0514 400 GPPETFDGTEAAQKALSCVYRTGQRFGAGHVIDVLRGSKNEKIRQFGHDKLSTYGIGKDLSDKEWRSVIRQLLA 473
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
5-586 |
0e+00 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 571.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 5 AAAQQVLKTTFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALLFQGITVVVSPLISLMKDQVDALNDNGI 84
Cdd:PRK11057 11 SLAKQVLQETFGYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALVLDGLTLVVSPLISLMKDQVDQLLANGV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 85 AATFINSSLDFQAINERLQELRAGDYTLLYVAPERLDSEYFIQALGRLPIQLLAIDEAHCISQWGHDFRPSYLALSTAIE 164
Cdd:PRK11057 91 AAACLNSTQTREQQLEVMAGCRTGQIKLLYIAPERLMMDNFLEHLAHWNPALLAVDEAHCISQWGHDFRPEYAALGQLRQ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 165 QLPTHPqVLALTATATEQVAADICGRLAIDPQHEVNTGFARDNLDLTVV-KDQDTDRYILdYLKVNHGEAGIIYASTRKE 243
Cdd:PRK11057 171 RFPTLP-FMALTATADDTTRQDIVRLLGLNDPLIQISSFDRPNIRYTLVeKFKPLDQLMR-YVQEQRGKSGIIYCNSRAK 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 244 VMRLTSLLQKHHINATPYHAGLDPEVRRHNQEDFLYDRVDVMVATNAFGMGIDKSNVRFVIHAQVPGTLEAYYQEAGRAG 323
Cdd:PRK11057 249 VEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYYQETGRAG 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 324 RDGLPSEAILLFRPNDIQLQHYFIDESE----MDTEhRHlayrKLQVMTRYANTQGCLQQFILKYFGE-DSEPCGRCSNC 398
Cdd:PRK11057 329 RDGLPAEAMLFYDPADMAWLRRCLEEKPagqqQDIE-RH----KLNAMGAFAEAQTCRRLVLLNYFGEgRQEPCGNCDIC 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 399 TDKREAKDITTAAQQVLSCVVRLHSRFGKGVVAQVLTGANNQRIRESHLEGLSTYGLMSGQRQKAVVELIDFLTASGYLQ 478
Cdd:PRK11057 404 LDPPKQYDGLEDAQKALSCIYRVNQRFGMGYVVEVLRGANNQRIRDYGHDKLKVYGIGRDKSHEHWVSVIRQLIHLGLVT 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 479 AVGGQYPTLTVTASGVDVLKGNTTV-----RRKTAQTVQQTVPENS----ALFEQLRTLRRQLAEEQGVPPFVIFSDKTL 549
Cdd:PRK11057 484 QNIAQHSALQLTEAARPVLRGEVSLqlavpRIVALKPRAMQKSFGGnydrKLFAKLRKLRKSIADEENIPPYVVFNDATL 563
|
570 580 590
....*....|....*....|....*....|....*..
gi 2440800153 550 HSMCEVMPEDDQAFLTVKGVGASKLEKYGETFMATIR 586
Cdd:PRK11057 564 IEMAEQMPITASEMLSVNGVGQRKLERFGKPFMALIR 600
|
|
| recQ_fam |
TIGR00614 |
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are ... |
9-454 |
1.84e-153 |
|
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129701 [Multi-domain] Cd Length: 470 Bit Score: 449.61 E-value: 1.84e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 9 QVLKTTFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALLFQGITVVVSPLISLMKDQVDALNDNGIAATF 88
Cdd:TIGR00614 1 KILKKYFGLSSFRPVQLEVINAVLLGRDCFVVMPTGGGKSLCYQLPALYSDGITLVISPLISLMEDQVLQLQALGIPATF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 89 INSSLDFQAINERLQELRAGDYTLLYVAPERL-DSEYFIQAL-GRLPIQLLAIDEAHCISQWGHDFRPSYLALSTAIEQL 166
Cdd:TIGR00614 81 LNSAQTKEQQLNVLTDLKDGKIKLLYVTPEKIsASNRLLQTLeERKGITLIAVDEAHCISQWGHDFRPDYKALGSLKQKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 167 PTHPqVLALTATATEQVAADICGRLAIDPQHEVNTGFARDNLDLTVVKD-----QDTDRYILDYLKvnhGEAGIIYASTR 241
Cdd:TIGR00614 161 PNVP-VMALTATASPSVREDILRQLNLLNPQIFCTSFDRPNLYYEVRRKtpkilEDLLRFIRKEFE---GKSGIIYCPSR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 242 KEVMRLTSLLQKHHINATPYHAGLDPEVRRHNQEDFLYDRVDVMVATNAFGMGIDKSNVRFVIHAQVPGTLEAYYQEAGR 321
Cdd:TIGR00614 237 KKVEQVAAELQKLGLAAGAYHAGLEDSARDDVQHKFQRDEIQVVVATVAFGMGINKPDVRFVIHYSLPKSMESYYQESGR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 322 AGRDGLPSEAILLFRPNDIQLQHYFIDEsEMDTEHRHLAYRKLQVMTRYANTQGCLQQFILKYFGED-----------SE 390
Cdd:TIGR00614 317 AGRDGLPSECHLFYAPADMNRLRRLLME-EPDGNFRTYKLKLYEMMEYCLNSSTCRRLILLSYFGEKgfnksfcimgtEK 395
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 391 PCGRCSNCTDKR------EAKDITTAAQQVLSCVVRLHSRFGKGVVAQVLTGANNQRIRESHLEGLSTYG 454
Cdd:TIGR00614 396 CCDNCCKRLDYKtkdvtdKVYDFGPQAQKALSAVGRLNQKFGMGYPVDFLRGSNSQKIRDGGFRKHSLYG 465
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
8-203 |
2.45e-102 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 308.31 E-value: 2.45e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 8 QQVLKTTFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALLFQGITVVVSPLISLMKDQVDALNDNGIAAT 87
Cdd:cd17920 1 EQILKEVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALLLDGVTLVVSPLISLMQDQVDRLQQLGIRAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 88 FINSSLDFQAINERLQELRAGDYTLLYVAPERLDSEYFIQALGRLP----IQLLAIDEAHCISQWGHDFRPSYLALSTAI 163
Cdd:cd17920 81 ALNSTLSPEEKREVLLRIKNGQYKLLYVTPERLLSPDFLELLQRLPerkrLALIVVDEAHCVSQWGHDFRPDYLRLGRLR 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 2440800153 164 EQLPtHPQVLALTATATEQVAADICGRLAIDPQHEVNTGF 203
Cdd:cd17920 161 RALP-GVPILALTATATPEVREDILKRLGLRNPVIFRASF 199
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
12-585 |
1.54e-98 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 325.70 E-value: 1.54e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 12 KTTFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALLFQGITVVVSPLISLMKDQVDALNDNGIAATFINS 91
Cdd:PLN03137 453 KKVFGNHSFRPNQREIINATMSGYDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVSLIQDQIMNLLQANIPAASLSA 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 92 SLDFQAINERLQELRAGD--YTLLYVAPERL-DSEYFIQALGRLPIQ-LLA---IDEAHCISQWGHDFRPSYLALSTAIE 164
Cdd:PLN03137 533 GMEWAEQLEILQELSSEYskYKLLYVTPEKVaKSDSLLRHLENLNSRgLLArfvIDEAHCVSQWGHDFRPDYQGLGILKQ 612
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 165 QLPTHPqVLALTATATEQVAADICGRLAIdpqheVN-----TGFARDNLDLTVVKD-----QDTDRYIldylKVNH-GEA 233
Cdd:PLN03137 613 KFPNIP-VLALTATATASVKEDVVQALGL-----VNcvvfrQSFNRPNLWYSVVPKtkkclEDIDKFI----KENHfDEC 682
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 234 GIIYASTRKEVMRLTSLLQKHHINATPYHAGLDPEVRRHNQEDFLYDRVDVMVATNAFGMGIDKSNVRFVIHAQVPGTLE 313
Cdd:PLN03137 683 GIIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIE 762
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 314 AYYQEAGRAGRDGLPSEAILLFRPND-IQLQHYF----IDESEMDTEHRHLAY--RKLQV-------MTRYA-NTQGCLQ 378
Cdd:PLN03137 763 GYHQECGRAGRDGQRSSCVLYYSYSDyIRVKHMIsqggVEQSPMAMGYNRMASsgRILETntenllrMVSYCeNEVDCRR 842
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 379 QFILKYFGE--DSEPCGR-CSNCTDKRE--AKDITTAAQQVLSCVVRLHSRFGKGVVAQVLTGANNQRIRESHLEGLSTY 453
Cdd:PLN03137 843 FLQLVHFGEkfDSTNCKKtCDNCSSSKSliDKDVTEIARQLVELVKLTGERFSSAHILEVYRGSLNQYVKKHRHETLSLH 922
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 454 G----LMSGQRQKAVVELI--DFL-----------TASGYLQA---------VGGQYPTL----TVTAS-----GVDVLK 498
Cdd:PLN03137 923 GagkhLSKGEASRILHYLVteDILaedvkksdlygSVSSLLKVneskayklfSGGQTIIMrfpsSVKASkpskfEATPAK 1002
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 499 GN------TTVRRKTAQTVQQTVPENSALFEQLRTLRRQLAEE--QGVPPFVIFSDKTLHSMCEVMPEDDQAFLTVKGVG 570
Cdd:PLN03137 1003 GPltsgkqSTLPMATPAQPPVDLNLSAILYTALRKLRTALVKEagDGVMAYHIFGNATLQQISKRIPRTKEELLEINGLG 1082
|
650
....*....|....*
gi 2440800153 571 ASKLEKYGETFMATI 585
Cdd:PLN03137 1083 KAKVSKYGDRLLETI 1097
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
9-204 |
1.54e-81 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 254.87 E-value: 1.54e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 9 QVLKTTFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALLFQ----GITVVVSPLISLMKDQVDALNDnGI 84
Cdd:cd18018 2 KLLRRVFGHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPALLLRrrgpGLTLVVSPLIALMKDQVDALPR-AI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 85 AATFINSSLDFQAINERLQELRAGDYTLLYVAPERLDSEYFIQAL-GRLPIQLLAIDEAHCISQWGHDFRPSYLALSTAI 163
Cdd:cd18018 81 KAAALNSSLTREERRRILEKLRAGEVKILYVSPERLVNESFRELLrQTPPISLLVVDEAHCISEWSHNFRPDYLRLCRVL 160
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 2440800153 164 EQLPTHPQVLALTATATEQVAADICGRLAIDPQHEVNTGFA 204
Cdd:cd18018 161 RELLGAPPVLALTATATKRVVEDIASHLGIPESGVVRGPLY 201
|
|
| DEXHc_RecQ1 |
cd18015 |
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ... |
6-194 |
2.23e-64 |
|
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350773 [Multi-domain] Cd Length: 209 Bit Score: 210.30 E-value: 2.23e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 6 AAQQVLKTTFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALLFQGITVVVSPLISLMKDQVDALNDNGIA 85
Cdd:cd18015 5 KVKDTLKNVFKLEKFRPLQLETINATMAGRDVFLVMPTGGGKSLCYQLPALCSDGFTLVVSPLISLMEDQLMALKKLGIS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 86 ATFINSSLDFQAINERLQELRAGD--YTLLYVAPERL-DSEYFIQAL------GRLpiQLLAIDEAHCISQWGHDFRPSY 156
Cdd:cd18015 85 ATMLNASSSKEHVKWVHAALTDKNseLKLLYVTPEKIaKSKRFMSKLekaynaGRL--ARIAIDEVHCCSQWGHDFRPDY 162
|
170 180 190
....*....|....*....|....*....|....*...
gi 2440800153 157 LALSTAIEQLPTHPqVLALTATATEQVAADICGRLAID 194
Cdd:cd18015 163 KKLGILKRQFPNVP-ILGLTATATSKVLKDVQKILCIQ 199
|
|
| DEXHc_RecQ3 |
cd18017 |
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ... |
11-203 |
4.39e-53 |
|
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ATP-dependent helicase or WRN) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Werner's syndrome.
Pssm-ID: 350775 [Multi-domain] Cd Length: 193 Bit Score: 179.97 E-value: 4.39e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 11 LKTTFGYDEFRPGQKAVIEQVL-AGENTLAIMPTGGGKSLCYQIPALLFQGITVVVSPLISLMKDQVDALNDNGIAATFI 89
Cdd:cd18017 4 LNEYFGHSSFRPVQWKVIRSVLeERRDNLVVMATGYGKSLCYQYPSVLLNSLTLVISPLISLMEDQVLQLVMSNIPACFL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 90 NSSldfQAINERlQELRAGDYTLLYVAPERLDSE-YFIQALgRLPIQLLAIDEAHCISQWGHDFRPSYLALSTAIEQLPT 168
Cdd:cd18017 84 GSA---QSQNVL-DDIKMGKIRVIYVTPEFVSKGlELLQQL-RNGITLIAIDEAHCVSQWGHDFRSSYRHLGSIRNRLPN 158
|
170 180 190
....*....|....*....|....*....|....*
gi 2440800153 169 HPqVLALTATATEQVAADICGRLAIDPQHEVNTGF 203
Cdd:cd18017 159 VP-IVALTATATPSVRDDIIKNLNLRNPQITCTSF 192
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
205-335 |
4.05e-51 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 172.39 E-value: 4.05e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 205 RDNLDLTVVKDQDTDRYILD--YLKVNH-GEAGIIYASTRKEVMRLTSLLQKHHINATPYHAGLDPEVRRHNQEDFLYDR 281
Cdd:cd18794 1 RPNLFYSVRPKDKKDEKLDLlkRIKVEHlGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 2440800153 282 VDVMVATNAFGMGIDKSNVRFVIHAQVPGTLEAYYQEAGRAGRDGLPSEAILLF 335
Cdd:cd18794 81 IQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECILFY 134
|
|
| DEXHc_RecQ2_BLM |
cd18016 |
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom ... |
9-193 |
2.13e-50 |
|
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom syndrome protein homolog or BLM) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations in RecQ2 cause Bloom syndrome.
Pssm-ID: 350774 [Multi-domain] Cd Length: 208 Bit Score: 173.09 E-value: 2.13e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 9 QVLKTTFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALLFQGITVVVSPLISLMKDQVDALNDNGIAATF 88
Cdd:cd18016 7 KIFHKKFGLHQFRTNQLEAINAALLGEDCFVLMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 89 INSSLDFQAINERLQELRAGD--YTLLYVAPERLD-SEYFIQALGRL-PIQLLA---IDEAHCISQWGHDFRPSYLALST 161
Cdd:cd18016 87 LTGDKTDAEATKIYLQLSKKDpiIKLLYVTPEKISaSNRLISTLENLyERKLLArfvIDEAHCVSQWGHDFRPDYKRLNM 166
|
170 180 190
....*....|....*....|....*....|..
gi 2440800153 162 AIEQLPTHPqVLALTATATEQVAADICGRLAI 193
Cdd:cd18016 167 LRQKFPSVP-MMALTATATPRVQKDILNQLKM 197
|
|
| DpdF |
NF041063 |
protein DpdF; |
10-342 |
1.64e-48 |
|
protein DpdF;
Pssm-ID: 468990 [Multi-domain] Cd Length: 813 Bit Score: 181.26 E-value: 1.64e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 10 VLKTTFGYDEFR-PGQKAVIEQVL---AGENTLAIMPTGGGKSLCYQIPALLF---QGITVVVSPLISLMKDQVDALNDN 82
Cdd:NF041063 130 FLAEALGFTHYRsPGQREAVRAALlapPGSTLIVNLPTGSGKSLVAQAPALLAsrqGGLTLVVVPTVALAIDQERRAREL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 83 GIAATFI----------NSSLDFQAINERLqelRAGDYTLLYVAPE----RLDSEYFIQA-LGRLpiQLLAIDEAHCISQ 147
Cdd:NF041063 210 LRRAGPDlggplawhggLSAEERAAIRQRI---RDGTQRILFTSPEsltgSLRPALFDAAeAGLL--RYLVVDEAHLVDQ 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 148 WGHDFRPSYLALSTAIEQL------PTHPQVLALTATATEQVAADIcGRLAIDPQH--EVNTGFARD----NLDLTVVKD 215
Cdd:NF041063 285 WGDGFRPEFQLLAGLRRSLlrlapsGRPFRTLLLSATLTESTLDTL-ETLFGPPGPfiVVSAVQLRPepayWVAKCDSEE 363
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 216 QDTDRYIldylkvnhgEA-------GIIYASTRKEVMRLTSLLQKHHIN--ATpYHAGLDPEVRRHNQEDFLYDRVDVMV 286
Cdd:NF041063 364 ERRERVL---------EAlrhlprpLILYVTKVEDAEAWLQRLRAAGFRrvAL-FHGDTPDAERERLIEQWRENELDIVV 433
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2440800153 287 ATNAFGMGIDKSNVRFVIHAQVPGTLEAYYQEAGRAGRDGLPSEAILLFRPNDIQL 342
Cdd:NF041063 434 ATSAFGLGMDKSDVRTVIHACVPETLDRFYQEVGRGGRDGKASLSLLIYTPDDLDI 489
|
|
| DEXHc_RecQ5 |
cd18014 |
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ ... |
8-193 |
5.00e-46 |
|
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350772 [Multi-domain] Cd Length: 205 Bit Score: 161.49 E-value: 5.00e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 8 QQVLKTTFGYDEFR-PGQKAVIEQVLAGE-NTLAIMPTGGGKSLCYQIPALLFQGITVVVSPLISLMKDQVDALNDNGIA 85
Cdd:cd18014 1 RSTLKKVFGHSDFKsPLQEKATMAVVKGNkDVFVCMPTGAGKSLCYQLPALLAKGITIVISPLIALIQDQVDHLKTLKIR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 86 ATFINSSLDFQAINERLQELRAG--DYTLLYVAPERLDSEYFIQALGRL----PIQLLAIDEAHCISQWGHDFRPSYLAL 159
Cdd:cd18014 81 VDSLNSKLSAQERKRIIADLESEkpQTKFLYITPEMAATSSFQPLLSSLvsrnLLSYLVVDEAHCVSQWGHDFRPDYLRL 160
|
170 180 190
....*....|....*....|....*....|....
gi 2440800153 160 STAIEQLPTHPQVlALTATATEQVAADICGRLAI 193
Cdd:cd18014 161 GALRSRYGHVPWV-ALTATATPQVQEDIFAQLRL 193
|
|
| RQC |
pfam09382 |
RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a ... |
402-506 |
7.37e-32 |
|
RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure. The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.
Pssm-ID: 462780 [Multi-domain] Cd Length: 108 Bit Score: 118.79 E-value: 7.37e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 402 REAKDITTAAQQVLSCVVRLHSRFGKGVVAQVLTGANNQRIRESHLEGLSTYGLMSGQRQKAVVELIDFLTASGYLQAVG 481
Cdd:pfam09382 2 PETVDVTEEAQKILSCVYRTGQRFGAGHLIDVLRGSKNKKIRQLGHDKLSTFGIGKDLSKKEWRRIIRQLIAEGYLEVDI 81
|
90 100
....*....|....*....|....*
gi 2440800153 482 GQYPTLTVTASGVDVLKGNTTVRRK 506
Cdd:pfam09382 82 EFYSVLKLTPKAREVLKGEEKVMLR 106
|
|
| RQC |
smart00956 |
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix ... |
406-497 |
1.34e-29 |
|
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.
Pssm-ID: 214936 [Multi-domain] Cd Length: 92 Bit Score: 112.18 E-value: 1.34e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 406 DITTAAQQVLSCVVRLHSRFGKGVVAQVLTGANNQRIRESHLEGLSTYGLMSGQRQKAVVELIDFLTASGYLQAVGGQYP 485
Cdd:smart00956 1 DVTEEAQKLLSCVYRTGQRFGAGHVIDVLRGSKNKKIRQKGHDRLSTFGIGKDLSKKEWRRLIRQLIAEGYLREDGGRYP 80
|
90
....*....|..
gi 2440800153 486 TLTVTASGVDVL 497
Cdd:smart00956 81 YLKLTEKARPVL 92
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
21-184 |
1.48e-29 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 114.65 E-value: 1.48e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 21 RPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPAL-----LFQGI-TVVVSPLISLMKDQVDALNDNGI-AATFINSSL 93
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALealdkLDNGPqALVLAPTRELAEQIYEELKKLGKgLGLKVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 94 DFQAINERLQELRAGDytLLYVAPERLDSeyFIQALGRLP-IQLLAIDEAHCISQWGhdFRPSYLALstaIEQLPTHPQV 172
Cdd:pfam00270 81 GGDSRKEQLEKLKGPD--ILVGTPGRLLD--LLQERKLLKnLKLLVLDEAHRLLDMG--FGPDLEEI---LRRLPKKRQI 151
|
170
....*....|..
gi 2440800153 173 LALTATATEQVA 184
Cdd:pfam00270 152 LLLSATLPRNLE 163
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
15-183 |
1.50e-24 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 101.41 E-value: 1.50e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 15 FGYDEFRPGQKAVIEQVLAGE-NTLAIMPTGGGKSLCYQIPALLF-----QGITVVVSPLISLMKDQVDALNDNGIAATF 88
Cdd:smart00487 4 FGFEPLRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEAlkrgkGGRVLVLVPTRELAEQWAEELKKLGPSLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 89 INSSL-DFQAINERLQELRAGDYTLLYVAPERLDSEYFIQALGRLPIQLLAIDEAHCISQWGhdFRPSYLALstaIEQLP 167
Cdd:smart00487 84 KVVGLyGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGG--FGDQLEKL---LKLLP 158
|
170
....*....|....*.
gi 2440800153 168 THPQVLALTATATEQV 183
Cdd:smart00487 159 KNVQLLLLSATPPEEI 174
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
220-326 |
5.47e-22 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 91.12 E-value: 5.47e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 220 RYILDYLKVNHGEAGIIYASTRKEVMrLTSLLQKHHINATPYHAGLDPEVRRHNQEDFLYDRVDVMVATNAFGMGIDKSN 299
Cdd:pfam00271 4 EALLELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPD 82
|
90 100
....*....|....*....|....*..
gi 2440800153 300 VRFVIHAQVPGTLEAYYQEAGRAGRDG 326
Cdd:pfam00271 83 VDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
24-351 |
1.81e-21 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 99.14 E-value: 1.81e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 24 QKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALlfQGI-------TVVVSPLISLMKDQVDALND------NGI-AATFI 89
Cdd:COG1205 61 QAEAIEAARAGKNVVIATPTASGKSLAYLLPVL--EALledpgatALYLYPTKALARDQLRRLRElaealgLGVrVATYD 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 90 NSSldfqAINERLQELRAGD----------YTLLYVAPErldseyFIQALGRLpiQLLAIDEAHcisqwghdfrpSY--- 156
Cdd:COG1205 139 GDT----PPEERRWIREHPDivltnpdmlhYGLLPHHTR------WARFFRNL--RYVVIDEAH-----------TYrgv 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 157 ----LA-----LSTAIEQLPTHPQVLALTATA--TEQVAADICGR--LAID----PQHEVNTGFAR-DNLDLTVVKDQDT 218
Cdd:COG1205 196 fgshVAnvlrrLRRICRHYGSDPQFILASATIgnPAEHAERLTGRpvTVVDedgsPRGERTFVLWNpPLVDDGIRRSALA 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 219 D-RYILDYLkVNHGEAGIIYASTRKEVMRLTSLLQKHHINA------TPYHAGLDPEVRRHNQEDFLYDRVDVMVATNAF 291
Cdd:COG1205 276 EaARLLADL-VREGLRTLVFTRSRRGAELLARYARRALREPdladrvAAYRAGYLPEERREIERGLRSGELLGVVSTNAL 354
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 292 GMGIDKSNVRFVIHAQVPGTLEAYYQEAGRAGRDGLPSEAILLFRPNdiQLQHYFIDESE 351
Cdd:COG1205 355 ELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDSLVVLVAGDD--PLDQYYVRHPE 412
|
|
| HRDC |
pfam00570 |
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ... |
520-585 |
1.86e-21 |
|
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.
Pssm-ID: 425755 [Multi-domain] Cd Length: 68 Bit Score: 87.98 E-value: 1.86e-21
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2440800153 520 ALFEQLRTLRRQLAEEQGVPPFVIFSDKTLHSMCEVMPEDDQAFLTVKGVGASKLEKYGETFMATI 585
Cdd:pfam00570 3 ALLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
246-326 |
1.05e-20 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 86.50 E-value: 1.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 246 RLTSLLQKHHINATPYHAGLDPEVRRHNQEDFLYDRVDVMVATNAFGMGIDKSNVRFVIHAQVPGTLEAYYQEAGRAGRD 325
Cdd:smart00490 2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRA 81
|
.
gi 2440800153 326 G 326
Cdd:smart00490 82 G 82
|
|
| RecQ_Zn_bind |
pfam16124 |
RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ. |
337-399 |
4.20e-20 |
|
RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ.
Pssm-ID: 465031 [Multi-domain] Cd Length: 66 Bit Score: 84.26 E-value: 4.20e-20
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2440800153 337 PNDIQLQHYFIDESEMDTEHRHLAYRKLQVMTRYA-NTQGCLQQFILKYFGE--DSEPCGRCSNCT 399
Cdd:pfam16124 1 YQDVVRLRFLIEQSEADEERKEVELQKLQAMVAYCeNTTDCRRKQLLRYFGEefDSEPCGNCDNCL 66
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
212-335 |
2.15e-16 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 76.01 E-value: 2.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 212 VVKDQDTDRYILDYLKVNH-GEAGIIYASTRKEVMRLTSLLQKHHINATPYHAGLDPEVRRHNQEDFLYDRVDVMVATNA 290
Cdd:cd18787 7 VVEEEEKKLLLLLLLLEKLkPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRVLVATDV 86
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2440800153 291 FGMGIDKSNVRFVIHAQVPGTLEAYYQEAGRAGRDGLPSEAILLF 335
Cdd:cd18787 87 AARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| HRDC |
smart00341 |
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the ... |
520-586 |
2.54e-16 |
|
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the HRDC domain cause human disease.
Pssm-ID: 128635 [Multi-domain] Cd Length: 81 Bit Score: 73.87 E-value: 2.54e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2440800153 520 ALFEQLRTLRRQLAEEQGVPPFVIFSDKTLHSMCEVMPEDDQAFLTVKGVGASKLEKYGETFMATIR 586
Cdd:smart00341 6 RLLRRLRQWRDEIARREDVPPYFVLPDETLIKMAAALPTNVSELLAIDGVGEEKARRYGKDLLAVIQ 72
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
16-342 |
3.03e-16 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 81.35 E-value: 3.03e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 16 GYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPalLFQGI---------TVVVSP---LIslmkDQV-DALNDN 82
Cdd:COG0513 21 GYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLP--LLQRLdpsrprapqALILAPtreLA----LQVaEELRKL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 83 GiAATFINSSLDF--QAINERLQELRAG-DytLLyVA-PERL-DseyFIQAlGRLP---IQLLAIDEAhcisqwghD--- 151
Cdd:COG0513 95 A-KYLGLRVATVYggVSIGRQIRALKRGvD--IV-VAtPGRLlD---LIER-GALDlsgVETLVLDEA--------Drml 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 152 ---FRPsylALSTAIEQLPTHPQVLALTATATEQVAAdICGRLAIDPQH-EVNT-GFARDNLDLTV--VKDQDTDRYILD 224
Cdd:COG0513 159 dmgFIE---DIERILKLLPKERQTLLFSATMPPEIRK-LAKRYLKNPVRiEVAPeNATAETIEQRYylVDKRDKLELLRR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 225 YLKVNHGEAGIIYASTRKEVMRLTSLLQKHHINATPYHAGLDPEVRRHNQEDFLYDRVDVMVATNAFGMGIDKSNVRFVI 304
Cdd:COG0513 235 LLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVI 314
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2440800153 305 HAQVPGTLEAYYQEAG---RAGRDGlpsEAILLFRPNDIQL 342
Cdd:COG0513 315 NYDLPEDPEDYVHRIGrtgRAGAEG---TAISLVTPDERRL 352
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
235-334 |
6.88e-16 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 74.99 E-value: 6.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 235 IIYASTRKE---VMRLT-SLLQKHHINAT---PYHAGLDPEVRRHNQEDFLYDRVDVMVATNAFGMGIDKSNVRFVIHAQ 307
Cdd:cd18797 39 IVFCRSRKLaelLLRYLkARLVEEGPLASkvaSYRAGYLAEDRREIEAELFNGELLGVVATNALELGIDIGGLDAVVLAG 118
|
90 100
....*....|....*....|....*..
gi 2440800153 308 VPGTLEAYYQEAGRAGRDGLPSEAILL 334
Cdd:cd18797 119 YPGSLASLWQQAGRAGRRGKDSLVILV 145
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
2-334 |
8.52e-16 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 80.32 E-value: 8.52e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 2 IDLAAAQQVLKTtFGYDEFRPGQKAVIEQ-VLAGENTLAIMPTGGGKSLCYQIPAL--LFQGITVV-VSPLISL----MK 73
Cdd:COG1204 6 LPLEKVIEFLKE-RGIEELYPPQAEALEAgLLEGKNLVVSAPTASGKTLIAELAILkaLLNGGKALyIVPLRALasekYR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 74 DQVDALNDNGIAATFinSSLDFQAINERLqelraGDYTLLYVAPERLDS-----EYFIQALGrlpiqLLAIDEAHCIsqw 148
Cdd:COG1204 85 EFKRDFEELGIKVGV--STGDYDSDDEWL-----GRYDILVATPEKLDSllrngPSWLRDVD-----LVVVDEAHLI--- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 149 GHDFR-PSY-LALSTAIEQLPThPQVLALTATA--TEQVAADICGRLAID-----PQHE-VNTGFARDNLDLTVVKDQDT 218
Cdd:COG1204 150 DDESRgPTLeVLLARLRRLNPE-AQIVALSATIgnAEEIAEWLDAELVKSdwrpvPLNEgVLYDGVLRFDDGSRRSKDPT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 219 DRYILDYLkvNHGEAGIIYASTRKEVM----RLTSLLQKHHINATPY--------------------------------- 261
Cdd:COG1204 229 LALALDLL--EEGGQVLVFVSSRRDAEslakKLADELKRRLTPEEREeleelaeellevseethtnekladclekgvafh 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 262 HAGLDPEVRRHNQEDFLYDRVDVMVATNAFGMGIdksN--VRFVI------HAQVP-GTLEaYYQEAGRAGRDGLPS--E 330
Cdd:COG1204 307 HAGLPSELRRLVEDAFREGLIKVLVATPTLAAGV---NlpARRVIirdtkrGGMVPiPVLE-FKQMAGRAGRPGYDPygE 382
|
....
gi 2440800153 331 AILL 334
Cdd:COG1204 383 AILV 386
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
34-178 |
4.76e-14 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 69.74 E-value: 4.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 34 GENTLAIMPTGGGKSLCYQIPALL----FQGITVVVSPLISLMKDQ---VDALNDNGIAATFINSSLDFqainERLQELR 106
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLlllkKGKKVLVLVPTKALALQTaerLRELFGPGIRVAVLVGGSSA----EEREKNK 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2440800153 107 AGDYTLLYVAPERLDSEYFIQALGRLP-IQLLAIDEAHCISQWGHDFRPSYLALstaIEQLPTHPQVLALTAT 178
Cdd:cd00046 77 LGDADIIIATPDMLLNLLLREDRLFLKdLKLIIVDEAHALLIDSRGALILDLAV---RKAGLKNAQVILLSAT 146
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
14-333 |
5.51e-11 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 65.19 E-value: 5.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 14 TFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALL------FQGIT-------VVVSP---LISLMKDQvd 77
Cdd:PLN00206 138 TAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISrcctirSGHPSeqrnplaMVLTPtreLCVQVEDQ-- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 78 alndngiaATFINSSLDFQ--------AINERLQELRAGdYTLLYVAPERLdseyfIQALGRLPIQL-----LAIDEAHC 144
Cdd:PLN00206 216 --------AKVLGKGLPFKtalvvggdAMPQQLYRIQQG-VELIVGTPGRL-----IDLLSKHDIELdnvsvLVLDEVDC 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 145 ISQWGhdFRPSYLALSTAIEQlpthPQVLALTAT---ATEQVAADICGRLAI-------DPQHEVNtgfardnlDLTV-V 213
Cdd:PLN00206 282 MLERG--FRDQVMQIFQALSQ----PQVLLFSATvspEVEKFASSLAKDIILisignpnRPNKAVK--------QLAIwV 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 214 KDQDTDRYILDYL--KVNHGEAGIIYASTR------KEVMRLTSLLQkhhinATPYHAGLDPEVRRHNQEDFLYDRVDVM 285
Cdd:PLN00206 348 ETKQKKQKLFDILksKQHFKPPAVVFVSSRlgadllANAITVVTGLK-----ALSIHGEKSMKERREVMKSFLVGEVPVI 422
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2440800153 286 VATNAFGMGIDKSNVRFVIHAQVPGTLEAYYQEAGRAGRDGLPSEAIL 333
Cdd:PLN00206 423 VATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIV 470
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
16-326 |
4.81e-10 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 62.24 E-value: 4.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 16 GYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQI-----------PALLFQG--ITVVVSP----LISLMKDQVDA 78
Cdd:PRK01297 106 GFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLIsiinqllqtppPKERYMGepRALIIAPtrelVVQIAKDAAAL 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 79 LNDNGIAATFINSSLDFqaiNERLQELRAGDYTLLYVAPERLDSeyFIQAlGRL---PIQLLAIDEAHCISQWGhdFRPS 155
Cdd:PRK01297 186 TKYTGLNVMTFVGGMDF---DKQLKQLEARFCDILVATPGRLLD--FNQR-GEVhldMVEVMVLDEADRMLDMG--FIPQ 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 156 ylaLSTAIEQLP--THPQVLALTATATEQVAaDICGRLAIDPQH-EVN-TGFARDNLD--LTVVKDQDTDRYILDYLKVN 229
Cdd:PRK01297 258 ---VRQIIRQTPrkEERQTLLFSATFTDDVM-NLAKQWTTDPAIvEIEpENVASDTVEqhVYAVAGSDKYKLLYNLVTQN 333
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 230 HGEAGIIYASTRKEVMRLTSLLQKHHINAtpyhAGLDPEVRRHNQ----EDFLYDRVDVMVATNAFGMGIDKSNVRFVIH 305
Cdd:PRK01297 334 PWERVMVFANRKDEVRRIEERLVKDGINA----AQLSGDVPQHKRiktlEGFREGKIRVLVATDVAGRGIHIDGISHVIN 409
|
330 340
....*....|....*....|.
gi 2440800153 306 AQVPGTLEAYYQEAGRAGRDG 326
Cdd:PRK01297 410 FTLPEDPDDYVHRIGRTGRAG 430
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
3-353 |
5.33e-10 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 61.77 E-value: 5.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 3 DLAAAQQVLKTTFGYDEFRPG--QKAVIEQVLAGENTLAIMPTGGGKSLCYQIPAL--------------------LFQG 60
Cdd:PTZ00424 32 ALKLNEDLLRGIYSYGFEKPSaiQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALqlidydlnacqalilaptreLAQQ 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 61 ITVVVSPLISLMKDQVDALndngIAATfinssldfqAINERLQELRAGDYtLLYVAPERLDSEYFIQALGRLPIQLLAID 140
Cdd:PTZ00424 112 IQKVVLALGDYLKVRCHAC----VGGT---------VVRDDINKLKAGVH-MVVGTPGRVYDMIDKRHLRVDDLKLFILD 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 141 EAHCISQWGhdFRpsyLALSTAIEQLPTHPQVLALTATATEQVAadicgrlaidpqhEVNTGFARDNLDLTVVKDQ---- 216
Cdd:PTZ00424 178 EADEMLSRG--FK---GQIYDVFKKLPPDVQVALFSATMPNEIL-------------ELTTKFMRDPKRILVKKDEltle 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 217 ---------DTDRYILDYLK-----VNHGEAgIIYASTRKEVMRLTSLLQKHHINATPYHAGLDPEVRRHNQEDFLYDRV 282
Cdd:PTZ00424 240 girqfyvavEKEEWKFDTLCdlyetLTITQA-IIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGST 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2440800153 283 DVMVATNAFGMGIDKSNVRFVIHAQVPGTLEAYYQEAGRAGRDGLPSEAILLFRPNDIQ----LQHYF---IDESEMD 353
Cdd:PTZ00424 319 RVLITTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEqlkeIERHYntqIEEMPME 396
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
32-342 |
3.24e-09 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 59.79 E-value: 3.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 32 LAGENTLAIMPTGGGKSLCYQIPA--------LLFQG---ITVVVSPLISLMKDQVDALNDNGIAATfINSSLDFQAINE 100
Cdd:PTZ00110 165 LSGRDMIGIAETGSGKTLAFLLPAivhinaqpLLRYGdgpIVLVLAPTRELAEQIREQCNKFGASSK-IRNTVAYGGVPK 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 101 RLQ--ELRAGDYTLLyVAPERLDS--EYFIQALGRlpIQLLAIDEAHCISQWGhdFRPSYLALstaIEQLPTHPQVLALT 176
Cdd:PTZ00110 244 RGQiyALRRGVEILI-ACPGRLIDflESNVTNLRR--VTYLVLDEADRMLDMG--FEPQIRKI---VSQIRPDRQTLMWS 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 177 ATATEQV---AADICGRlaiDPQHeVNTGfardNLDLTVVKDQDTDRYILD------YLK------VNHGEAGIIYASTR 241
Cdd:PTZ00110 316 ATWPKEVqslARDLCKE---EPVH-VNVG----SLDLTACHNIKQEVFVVEehekrgKLKmllqriMRDGDKILIFVETK 387
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 242 KEVMRLTSLLQKHHINATPYHAGLDPEVRRHNQEDFLYDRVDVMVATNAFGMGIDKSNVRFVIHAQVPGTLEAYYQEAGR 321
Cdd:PTZ00110 388 KGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGR 467
|
330 340
....*....|....*....|.
gi 2440800153 322 AGRDGLPSEAILLFRPNDIQL 342
Cdd:PTZ00110 468 TGRAGAKGASYTFLTPDKYRL 488
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
3-338 |
4.66e-09 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 59.09 E-value: 4.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 3 DLAAAQQVLK--TTFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPAL------LFQGITVVVSPLISLMKD 74
Cdd:PRK11634 10 DLGLKAPILEalNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLhnldpeLKAPQILVLAPTRELAVQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 75 QVDALND-----NGI--AATFINSSLDFQainerLQELRAGDyTLLYVAPERLdseyfIQALGRLPIQL-----LAIDEA 142
Cdd:PRK11634 90 VAEAMTDfskhmRGVnvVALYGGQRYDVQ-----LRALRQGP-QIVVGTPGRL-----LDHLKRGTLDLsklsgLVLDEA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 143 HCISQWG--HDfrpsylaLSTAIEQLPTHPQVLALTATATEQVAAdICGRLAIDPQhEV---NTGFARDNLDLT--VVKD 215
Cdd:PRK11634 159 DEMLRMGfiED-------VETIMAQIPEGHQTALFSATMPEAIRR-ITRRFMKEPQ-EVriqSSVTTRPDISQSywTVWG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 216 QDTDRYILDYLKVNHGEAGIIYASTRKEVMRLTSLLQKHHINATPYHAGLDPEVRRHNQEDFLYDRVDVMVATNAFGMGI 295
Cdd:PRK11634 230 MRKNEALVRFLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGL 309
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 2440800153 296 DKSNVRFVIHAQVPGTLEAYYQEAGRAGRDGLPSEAiLLFRPN 338
Cdd:PRK11634 310 DVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRA-LLFVEN 351
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
278-334 |
2.94e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 50.78 E-value: 2.94e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 2440800153 278 LYDRVDVMVATNAFGMGIDKSNVRFVIHAQVPGTLEAYYQEAGRAGRDG-LPSEAILL 334
Cdd:cd18785 19 IASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGkDEGEVILF 76
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
16-334 |
2.86e-07 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 53.27 E-value: 2.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 16 GYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPalLFQGIT--------------VVVSPLISLMKdQVDALND 81
Cdd:PRK10590 20 GYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLP--LLQHLItrqphakgrrpvraLILTPTRELAA-QIGENVR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 82 NGIAATFINSSLDFQ--AINERLQELRAGdYTLLYVAPERL-DSEYfIQALGRLPIQLLAIDEAHCISQWG--HDFRpsy 156
Cdd:PRK10590 97 DYSKYLNIRSLVVFGgvSINPQMMKLRGG-VDVLVATPGRLlDLEH-QNAVKLDQVEILVLDEADRMLDMGfiHDIR--- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 157 lalsTAIEQLPTHPQVLALTATATEQVAAdICGRLAIDP-QHEVntgfARDNLDLTVVK------DQDTDRYILDYL-KV 228
Cdd:PRK10590 172 ----RVLAKLPAKRQNLLFSATFSDDIKA-LAEKLLHNPlEIEV----ARRNTASEQVTqhvhfvDKKRKRELLSQMiGK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 229 NHGEAGIIYASTRKEVMRLTSLLQKHHINATPYHAGLDPEVRRHNQEDFLYDRVDVMVATNAFGMGIDKSNVRFVIHAQV 308
Cdd:PRK10590 243 GNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYEL 322
|
330 340
....*....|....*....|....*.
gi 2440800153 309 PGTLEAYYQEAGRAGRDGLPSEAILL 334
Cdd:PRK10590 323 PNVPEDYVHRIGRTGRAAATGEALSL 348
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
16-351 |
2.78e-06 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 50.59 E-value: 2.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 16 GYDEFRPGQ-KAVIEQVLAGENTLAIMPTGGGKSLCYQIP---ALLFQ-GITVVVSPLISLMKDQVDALND-NGIAATFI 89
Cdd:PRK00254 20 GIEELYPPQaEALKSGVLEGKNLVLAIPTASGKTLVAEIVmvnKLLREgGKAVYLVPLKALAEEKYREFKDwEKLGLRVA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 90 NSSLDFQAINERLqelraGDYTLLYVAPERLDSEYFIQALGRLPIQLLAIDEAHCISQwghdfRPSYLALSTAIEQLPTH 169
Cdd:PRK00254 100 MTTGDYDSTDEWL-----GKYDIIIATAEKFDSLLRHGSSWIKDVKLVVADEIHLIGS-----YDRGATLEMILTHMLGR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 170 PQVLALTATA--TEQVAADICGRLAIDPQHEVNTGFARDNLDLTVVKDQDTDRYI-----LDYLKVNHGEAGIIYASTR- 241
Cdd:PRK00254 170 AQILGLSATVgnAEELAEWLNAELVVSDWRPVKLRKGVFYQGFLFWEDGKIERFPnswesLVYDAVKKGKGALVFVNTRr 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 242 ---KEVMRLTSLLQKH--------------HINATP---------------YHAGLDPEVRRHNQEDFLYDRVDVMVATN 289
Cdd:PRK00254 250 saeKEALELAKKIKRFltkpelralkeladSLEENPtneklkkalrggvafHHAGLGRTERVLIEDAFREGLIKVITATP 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 290 AFGMGIDKSNVRFVIH----------AQVPgTLEAyYQEAGRAGRdglP-----SEAILLFR---PNDIqLQHYFIDESE 351
Cdd:PRK00254 330 TLSAGINLPAFRVIIRdtkrysnfgwEDIP-VLEI-QQMMGRAGR---PkydevGEAIIVATteePSKL-MERYIFGKPE 403
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
226-342 |
3.32e-06 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 49.94 E-value: 3.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 226 LKVNHGEAGIIYASTRKEVMRLTSLLQKHHINATpYHAGLDPEVRRHNQEDFLYD-RVDVMVATNAFGMGIDKSNVRFVI 304
Cdd:PRK11192 240 LKQPEVTRSIVFVRTRERVHELAGWLRKAGINCC-YLEGEMVQAKRNEAIKRLTDgRVNVLVATDVAARGIDIDDVSHVI 318
|
90 100 110
....*....|....*....|....*....|....*...
gi 2440800153 305 HAQVPGTLEAYYQEAGRAGRDGLPSEAILLFRPNDIQL 342
Cdd:PRK11192 319 NFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHLL 356
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
19-178 |
3.65e-06 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 47.28 E-value: 3.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 19 EFRPGQKAVIEQVLAG-----ENTLAIMPTGGGKSLCY-QIPALLFQ----GITVVVSPLISLMKDQVDALNDNGIAATF 88
Cdd:pfam04851 3 ELRPYQIEAIENLLESikngqKRGLIVMATGSGKTLTAaKLIARLFKkgpiKKVLFLVPRKDLLEQALEEFKKFLPNYVE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 89 INSSL-----DFQAINERL-----QELragdYTLLYVAPERLDSEYFIqalgrlpiqLLAIDEAHcisqwgHDFRPSYla 158
Cdd:pfam04851 83 IGEIIsgdkkDESVDDNKIvvttiQSL----YKALELASLELLPDFFD---------VIIIDEAH------RSGASSY-- 141
|
170 180
....*....|....*....|
gi 2440800153 159 lsTAIEQLPTHPQVLALTAT 178
Cdd:pfam04851 142 --RNILEYFKPAFLLGLTAT 159
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
196-334 |
1.28e-05 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 45.62 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 196 QHEV---NTGFARDNLDLTVVKDQDtDRYILDYLKVNHGEAGIIYASTRKEVMRLTSLLqkhhINATPYHAGLDPEVRRH 272
Cdd:cd18795 6 EEYVlgfNGLGIKLRVDVMNKFDSD-IIVLLKIETVSEGKPVLVFCSSRKECEKTAKDL----AGIAFHHAGLTREDREL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2440800153 273 NQEDFLYDRVDVMVATNAFGMGID--------KSNVRFVIHAQVPGTLEAYYQEAGRAGRDGLPS--EAILL 334
Cdd:cd18795 81 VEELFREGLIKVLVATSTLAAGVNlpartviiKGTQRYDGKGYRELSPLEYLQMIGRAGRPGFDTrgEAIIM 152
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
19-191 |
1.55e-05 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 45.79 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 19 EFRPGQKAVIEQ-VLAGENTLAIMPTGGGKSLCYQ---IPALLFQGITVVVSPLISLMKDQVDALND-NGIAATFINSSL 93
Cdd:cd18028 1 ELYPPQAEAVRAgLLKGENLLISIPTASGKTLIAEmamVNTLLEGGKALYLVPLRALASEKYEEFKKlEEIGLKVGISTG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 94 DFQAINERLqelraGDYTLLYVAPERLDS-----EYFIQALGrlpiqLLAIDEAHCISQWGHDfrPSYLALSTAIEQLPT 168
Cdd:cd18028 81 DYDEDDEWL-----GDYDIIVATYEKFDSllrhsPSWLRDVG-----VVVVDEIHLISDEERG--PTLESIVARLRRLNP 148
|
170 180
....*....|....*....|....*
gi 2440800153 169 HPQVLALTATA--TEQVAADICGRL 191
Cdd:cd18028 149 NTQIIGLSATIgnPDELAEWLNAEL 173
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
24-143 |
4.95e-05 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 44.50 E-value: 4.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 24 QKAVIEQVLAGENTLAIMPTGGGKSLCYQIPAL--LFQ--GIT-VVVSPLISLMKDQVDALND--NGIAATFINSSLDFQ 96
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILeaLLRdpGSRaLYLYPTKALAQDQLRSLREllEQLGLGIRVATYDGD 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2440800153 97 AINERLQELRAGDYTLLYVAPERLD------SEYFIQALGRLpiQLLAIDEAH 143
Cdd:cd17923 85 TPREERRAIIRNPPRILLTNPDMLHyallphHDRWARFLRNL--RYVVLDEAH 135
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
19-179 |
9.72e-05 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 43.40 E-value: 9.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 19 EFRPGQKAVIEQV-LAGENTLAIMPTGGGKSLC--YQIPALLFQGITVVV--SPLISLMKDQVDALNDngiaaTFINSSL 93
Cdd:cd17921 1 LLNPIQREALRALyLSGDSVLVSAPTSSGKTLIaeLAILRALATSGGKAVyiAPTRALVNQKEADLRE-----RFGPLGK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 94 DFQAI--NERLQELRAGDYTLLYVAPERLDSE-YFIQALGRLPIQLLAIDEAHCISQwghDFR-PSYLALSTAIEQLPTH 169
Cdd:cd17921 76 NVGLLtgDPSVNKLLLAEADILVATPEKLDLLlRNGGERLIQDVRLVVVDEAHLIGD---GERgVVLELLLSRLLRINKN 152
|
170
....*....|
gi 2440800153 170 PQVLALTATA 179
Cdd:cd17921 153 ARFVGLSATL 162
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
206-324 |
1.23e-04 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 42.64 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 206 DNLDLTVVKDQDTDRYILDYLKVNHGEAGIIYASTRKEVMRLTSLLQKHHINATP------YHAGLDPEVRRHNQEDFLY 279
Cdd:cd18796 13 APEIFPWAGESGADAYAEVIFLLERHKSTLVFTNTRSQAERLAQRLRELCPDRVPpdfialHHGSLSRELREEVEAALKR 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 2440800153 280 DRVDVMVATNAFGMGIDKSNVRFVIhaQV--PGTLEAYYQEAGRAGR 324
Cdd:cd18796 93 GDLKVVVATSSLELGIDIGDVDLVI--QIgsPKSVARLLQRLGRSGH 137
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
240-327 |
1.28e-04 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 42.16 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 240 TRKEVMRLTSLLQKH-HINATPYHAGLDPEVRRH-----NQEDFLYDrvdVMVATNAFGMGIDkSNVRFVI--------- 304
Cdd:cd18805 26 SRKDIFSLKREIEKRtGLKCAVIYGALPPETRRQqarlfNDPESGYD---VLVASDAIGMGLN-LNIRRVIfsslskfdg 101
|
90 100
....*....|....*....|...
gi 2440800153 305 HAQVPGTLEAYYQEAGRAGRDGL 327
Cdd:cd18805 102 NEMRPLSPSEVKQIAGRAGRFGS 124
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
20-178 |
1.38e-04 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 42.29 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 20 FRPGQKAVIEQVLAGENT---LAIMPTGGGKSLC-YQIPALLFQGITVVVSPLISLMKDQVDALND-NGIAATFINSSLD 94
Cdd:cd17926 1 LRPYQEEALEAWLAHKNNrrgILVLPTGSGKTLTaLALIAYLKELRTLIVVPTDALLDQWKERFEDfLGDSSIGLIGGGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 95 FQAINERlqelragdytLLYVApeRLDSEYFIQALGRLPIQ---LLAIDEAHCIS--QWGHdfrpsylalstAIEQLPTH 169
Cdd:cd17926 81 KKDFDDA----------NVVVA--TYQSLSNLAEEEKDLFDqfgLLIVDEAHHLPakTFSE-----------ILKELNAK 137
|
....*....
gi 2440800153 170 PQvLALTAT 178
Cdd:cd17926 138 YR-LGLTAT 145
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
16-185 |
2.10e-04 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 42.98 E-value: 2.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 16 GYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALlfQGIT--------VVVSPLISL---MKDQVDALNDN-G 83
Cdd:cd17955 18 GIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPIL--QRLSedpygifaLVLTPTRELayqIAEQFRALGAPlG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 84 IAATFINSSLDF--QAInerlqELRAGDYTLlyVA-PERL-----DSEYFIQALGRlpIQLLAIDEAHCIsqWGHDFRPS 155
Cdd:cd17955 96 LRCCVIVGGMDMvkQAL-----ELSKRPHIV--VAtPGRLadhlrSSDDTTKVLSR--VKFLVLDEADRL--LTGSFEDD 164
|
170 180 190
....*....|....*....|....*....|
gi 2440800153 156 ylaLSTAIEQLPTHPQVLALTATATEQVAA 185
Cdd:cd17955 165 ---LATILSALPPKRQTLLFSATLTDALKA 191
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
235-324 |
2.15e-04 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 44.50 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 235 IIYASTRKEVMRLTSLLQkhhINATPYHAGLDPEVRRHNQEDFLYDRVDVMVATNAFGMGID--KSNVRFVIHAQvpG-- 310
Cdd:COG1202 431 IIFTNSRRRCHEIARALG---YKAAPYHAGLDYGERKKVERRFADQELAAVVTTAALAAGVDfpASQVIFDSLAM--Gie 505
|
90
....*....|....*.
gi 2440800153 311 --TLEAYYQEAGRAGR 324
Cdd:COG1202 506 wlSVQEFHQMLGRAGR 521
|
|
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
19-66 |
1.68e-03 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 41.45 E-value: 1.68e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 2440800153 19 EFRPGQKAVIEQV---LAGENTLAI-MPTGGGKSLCYQIPALLF---QGITVVVS 66
Cdd:COG1199 14 EPRPGQREMAEAVaraLAEGRHLLIeAGTGTGKTLAYLVPALLAareTGKKVVIS 68
|
|
| Rnd |
COG0349 |
Ribonuclease D [Translation, ribosomal structure and biogenesis]; |
520-586 |
1.79e-03 |
|
Ribonuclease D [Translation, ribosomal structure and biogenesis];
Pssm-ID: 440118 [Multi-domain] Cd Length: 365 Bit Score: 41.01 E-value: 1.79e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2440800153 520 ALFEQLRTLRRQLAEEQGVPPFVIFSDKTLHSMCEVMPEDDQAFLTVKGVGASKLEKYGETFMATIR 586
Cdd:COG0349 211 AVLRELAAWREREARKRDVPRNRVLKDEALLELARRQPKSLEELARLRGLSPGEIRRHGEELLAAVA 277
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
16-56 |
2.15e-03 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 39.73 E-value: 2.15e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 2440800153 16 GYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPAL 56
Cdd:cd00268 9 GFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPIL 49
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
34-178 |
2.60e-03 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 39.10 E-value: 2.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 34 GENTLAIMPTGGGKSLCYQIPAL--LF----QGITVV-VSPLISLMKDQVDALND--NGIAAtfinssldfqainERLQE 104
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALssLAdepeKGVQVLyISPLKALINDQERRLEEplDEIDL-------------EIPVA 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2440800153 105 LRAGDYT-------------LLYVAPERLD----SEYFIQALGRLpiQLLAIDEAHCISQwghDFRPSYLALSTA-IEQL 166
Cdd:cd17922 68 VRHGDTSqsekakqlknppgILITTPESLElllvNKKLRELFAGL--RYVVVDEIHALLG---SKRGVQLELLLErLRKL 142
|
170
....*....|...
gi 2440800153 167 P-THPQVLALTAT 178
Cdd:cd17922 143 TgRPLRRIGLSAT 155
|
|
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
262-327 |
5.37e-03 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 39.92 E-value: 5.37e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2440800153 262 HAGLDPEVRRHNQEDFLYDRVDVMVATNAFGMGIdksNV--RFVI---------HAQVPGTLEAYYQEAGRAGRDGL 327
Cdd:COG4581 306 HAGMLPKYRRLVEELFQAGLLKVVFATDTLAVGI---NMpaRTVVftklskfdgERHRPLTAREFHQIAGRAGRRGI 379
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
15-79 |
7.03e-03 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 38.33 E-value: 7.03e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2440800153 15 FGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALlfqgiTVVVSPLISLMKDQVDAL 79
Cdd:cd17960 8 LGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVL-----EILLKRKANLKKGQVGAL 67
|
|
| |
