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Conserved domains on  [gi|490997821|ref|WP_004859547|]
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MULTISPECIES: ribosome silencing factor [Enterobacteriaceae]

Protein Classification

ribosome silencing factor RsfS( domain architecture ID 10013827)

ribosome silencing factor RsfS represses translation by preventing the association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11538 PRK11538
ribosome silencing factor;
1-105 8.17e-70

ribosome silencing factor;


:

Pssm-ID: 183184  Cd Length: 105  Bit Score: 203.49  E-value: 8.17e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490997821   1 MQGKALQDFVIDKIDDLKGQDIVAIDVHGKSSITDCMIICTGTSTRHVMSIADHVVQESRAAGMLPLGVEGESAADWIVV 80
Cdd:PRK11538   1 MQGKALQDFVIDKIDDLKGQDIIALDVQGKSSITDCMIICTGTSSRHVMSIADHVVQESRAAGLLPLGVEGENAADWIVV 80

                         90       100
                 ....*....|....*....|....*
gi 490997821  81 DLGDVMVHVMQEESRRLYELEKLWS 105
Cdd:PRK11538  81 DLGDVIVHVMQEESRRLYELEKLWS 105
 
Name Accession Description Interval E-value
PRK11538 PRK11538
ribosome silencing factor;
1-105 8.17e-70

ribosome silencing factor;


Pssm-ID: 183184  Cd Length: 105  Bit Score: 203.49  E-value: 8.17e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490997821   1 MQGKALQDFVIDKIDDLKGQDIVAIDVHGKSSITDCMIICTGTSTRHVMSIADHVVQESRAAGMLPLGVEGESAADWIVV 80
Cdd:PRK11538   1 MQGKALQDFVIDKIDDLKGQDIIALDVQGKSSITDCMIICTGTSSRHVMSIADHVVQESRAAGLLPLGVEGENAADWIVV 80

                         90       100
                 ....*....|....*....|....*
gi 490997821  81 DLGDVMVHVMQEESRRLYELEKLWS 105
Cdd:PRK11538  81 DLGDVIVHVMQEESRRLYELEKLWS 105
RsfS COG0799
Ribosomal silencing factor RsfS, regulates association of 30S and 50S subunits [Translation, ...
 1-105 2.42e-51

Ribosomal silencing factor RsfS, regulates association of 30S and 50S subunits [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440562  Cd Length: 113  Bit Score: 157.20  E-value: 2.42e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490997821   1 MQGKALQDFVIDKIDDLKGQDIVAIDVHGKSSITDCMIICTGTSTRHVMSIADHVVQESRAAGMLPLGVEGESAADWIVV 80
Cdd:COG0799    3 MDSEELLKLIAKALDDKKAEDIVVLDVRGLSSIADYFVIASGTSDRQVKAIADEVEEKLKEAGIKPLRVEGLDEGEWVLL 82

                         90       100
                 ....*....|....*....|....*
gi 490997821  81 DLGDVMVHVMQEESRRLYELEKLWS 105
Cdd:COG0799   83 DYGDVVVHIFQPEVREFYNLERLWG 107
rsfS_iojap_ybeB TIGR00090
ribosome silencing factor RsfS/YbeB/iojap; This model describes a widely distributed family of ...
 6-104 7.77e-51

ribosome silencing factor RsfS/YbeB/iojap; This model describes a widely distributed family of bacterial proteins related to iojap from plants. It includes RsfS(YbeB) from E. coli. The gene iojap is a pattern-striping gene in maize, reflecting a chloroplast development defect in some cells. The conserved function of this protein is to silence ribosomes by binding the ribosomal large subunit and impairing joining with the small subunit in response to nutrient stress. Note that RsfS (starvation) is an author-endorsed change from the published symbol RsfA, which conflicted with previously published gene symbols. [Protein synthesis, Translation factors]


Pssm-ID: 272901  Cd Length: 99  Bit Score: 155.31  E-value: 7.77e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490997821    6 LQDFVIDKIDDLKGQDIVAIDVHGKSSITDCMIICTGTSTRHVMSIADHVVQESRAAGMLPLGVEGESAADWIVVDLGDV 85
Cdd:TIGR00090   1 LLELIVEALDDKKAEDIVVLDVRGKSSIADYFVIASGTSSRHVKAIADNVKEELKEAGLKPLGVEGLEEGDWVLVDLGDV 80

                          90
                  ....*....|....*....
gi 490997821   86 MVHVMQEESRRLYELEKLW 104
Cdd:TIGR00090  81 VVHIFTPEAREFYDLEKLW 99
RsfS pfam02410
Ribosomal silencing factor during starvation; This family is expressed by almost all bacterial ...
 8-104 2.60e-46

Ribosomal silencing factor during starvation; This family is expressed by almost all bacterial and eukaryotic genomes but not by archaea. Its function is to down-regulate protein synthesis under conditions of nutrient shortage, and it does this by binding to protein L14 of the large ribosomal subunit, thus acting as a ribosomal silencing factor (RsfS) by blocking the joining of the ribosomal subunits. This family is structurally homologous to nucleotidyltransferases.


Pssm-ID: 460550  Cd Length: 97  Bit Score: 143.74  E-value: 2.60e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490997821    8 DFVIDKIDDLKGQDIVAIDVHGKSSITDCMIICTGTSTRHVMSIADHVVQESRAAGMLPLGVEGESAADWIVVDLGDVMV 87
Cdd:pfam02410   1 ELIAEALDDKKAEDIVVLDVRGKSSIADYFVIATGTSERHVRAIADEVEEKLKEAGGKPLRIEGLREGDWVLLDYGDVVV 80

                          90
                  ....*....|....*..
gi 490997821   88 HVMQEESRRLYELEKLW 104
Cdd:pfam02410  81 HIFTPEAREFYNLERLW 97
 
Name Accession Description Interval E-value
PRK11538 PRK11538
ribosome silencing factor;
1-105 8.17e-70

ribosome silencing factor;


Pssm-ID: 183184  Cd Length: 105  Bit Score: 203.49  E-value: 8.17e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490997821   1 MQGKALQDFVIDKIDDLKGQDIVAIDVHGKSSITDCMIICTGTSTRHVMSIADHVVQESRAAGMLPLGVEGESAADWIVV 80
Cdd:PRK11538   1 MQGKALQDFVIDKIDDLKGQDIIALDVQGKSSITDCMIICTGTSSRHVMSIADHVVQESRAAGLLPLGVEGENAADWIVV 80

                         90       100
                 ....*....|....*....|....*
gi 490997821  81 DLGDVMVHVMQEESRRLYELEKLWS 105
Cdd:PRK11538  81 DLGDVIVHVMQEESRRLYELEKLWS 105
RsfS COG0799
Ribosomal silencing factor RsfS, regulates association of 30S and 50S subunits [Translation, ...
 1-105 2.42e-51

Ribosomal silencing factor RsfS, regulates association of 30S and 50S subunits [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440562  Cd Length: 113  Bit Score: 157.20  E-value: 2.42e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490997821   1 MQGKALQDFVIDKIDDLKGQDIVAIDVHGKSSITDCMIICTGTSTRHVMSIADHVVQESRAAGMLPLGVEGESAADWIVV 80
Cdd:COG0799    3 MDSEELLKLIAKALDDKKAEDIVVLDVRGLSSIADYFVIASGTSDRQVKAIADEVEEKLKEAGIKPLRVEGLDEGEWVLL 82

                         90       100
                 ....*....|....*....|....*
gi 490997821  81 DLGDVMVHVMQEESRRLYELEKLWS 105
Cdd:COG0799   83 DYGDVVVHIFQPEVREFYNLERLWG 107
rsfS_iojap_ybeB TIGR00090
ribosome silencing factor RsfS/YbeB/iojap; This model describes a widely distributed family of ...
 6-104 7.77e-51

ribosome silencing factor RsfS/YbeB/iojap; This model describes a widely distributed family of bacterial proteins related to iojap from plants. It includes RsfS(YbeB) from E. coli. The gene iojap is a pattern-striping gene in maize, reflecting a chloroplast development defect in some cells. The conserved function of this protein is to silence ribosomes by binding the ribosomal large subunit and impairing joining with the small subunit in response to nutrient stress. Note that RsfS (starvation) is an author-endorsed change from the published symbol RsfA, which conflicted with previously published gene symbols. [Protein synthesis, Translation factors]


Pssm-ID: 272901  Cd Length: 99  Bit Score: 155.31  E-value: 7.77e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490997821    6 LQDFVIDKIDDLKGQDIVAIDVHGKSSITDCMIICTGTSTRHVMSIADHVVQESRAAGMLPLGVEGESAADWIVVDLGDV 85
Cdd:TIGR00090   1 LLELIVEALDDKKAEDIVVLDVRGKSSIADYFVIASGTSSRHVKAIADNVKEELKEAGLKPLGVEGLEEGDWVLVDLGDV 80

                          90
                  ....*....|....*....
gi 490997821   86 MVHVMQEESRRLYELEKLW 104
Cdd:TIGR00090  81 VVHIFTPEAREFYDLEKLW 99
RsfS pfam02410
Ribosomal silencing factor during starvation; This family is expressed by almost all bacterial ...
 8-104 2.60e-46

Ribosomal silencing factor during starvation; This family is expressed by almost all bacterial and eukaryotic genomes but not by archaea. Its function is to down-regulate protein synthesis under conditions of nutrient shortage, and it does this by binding to protein L14 of the large ribosomal subunit, thus acting as a ribosomal silencing factor (RsfS) by blocking the joining of the ribosomal subunits. This family is structurally homologous to nucleotidyltransferases.


Pssm-ID: 460550  Cd Length: 97  Bit Score: 143.74  E-value: 2.60e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490997821    8 DFVIDKIDDLKGQDIVAIDVHGKSSITDCMIICTGTSTRHVMSIADHVVQESRAAGMLPLGVEGESAADWIVVDLGDVMV 87
Cdd:pfam02410   1 ELIAEALDDKKAEDIVVLDVRGKSSIADYFVIATGTSERHVRAIADEVEEKLKEAGGKPLRIEGLREGDWVLLDYGDVVV 80

                          90
                  ....*....|....*..
gi 490997821   88 HVMQEESRRLYELEKLW 104
Cdd:pfam02410  81 HIFTPEAREFYNLERLW 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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