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Conserved domains on  [gi|502374592|ref|WP_012775196|]
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pneumococcal-type histidine triad protein [Streptococcus suis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
strep_his_triad super family cl36882
streptococcal histidine triad protein; This model represents the N-terminal half of a family ...
 1-241 9.04e-11

streptococcal histidine triad protein; This model represents the N-terminal half of a family of Streptococcal proteins that contain a signal peptide and then up to five repeats of a region that includes a His-X-X-His-X-His (histidine triad) motif. Three repeats are found in the seed alignment. Additional copies in more poorly conserved regions may be detected. Members of this family from Streptococcus pneumoniae are suggested to cleave human C3, and the member PhpA has been shown in vaccine studies to be a protective antigen in mice. [Cellular processes, Pathogenesis]


The actual alignment was detected with superfamily member TIGR01363:

Pssm-ID: 273578 [Multi-domain]  Cd Length: 348  Bit Score: 64.21  E-value: 9.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502374592    1 MKQGKTllYVAGASLICAVALVTYQASNY--REQSNHQKTTSIETSQSKQSKE--IPSD-SKKEvpGIDKatddgflltd 75
Cdd:TIGR01363   1 MKINKK--YLGGSAAILLLSVCSYELGKYqaGSAKEDNRVAYIDGSQAKQKKEnlTPDEvSKRE--GINA---------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502374592   76 ESQIEEKTDLGIIVNHGDHKHFF-------------------------------------------FYSDLK------NT 106
Cdd:TIGR01363  67 EQIVIKITDQGYVTSHGDHYHYYngkvpydaiiseellmkdpnyrlkdsdivneikggyvikvngkYYVYLKdaahadNI 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502374592  107 KWAYLIPENYQEKNHSSQPKRSQ--------LSSGSKQIEDEYVFDPKDIVAEDANGYTVRHGDHYHYILKSSL------ 172
Cdd:TIGR01363 147 RTKEEIARQKQEGSKEAKEKSKRedaavaeaRRQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELsasela 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502374592  173 -------GGTTHRQLTSDSRQ------------SPTLPIV----------HQQEGIPGIDFQT----------------S 207
Cdd:TIGR01363 227 aaeaywsGKQGRGARPSDYRQgsrkasipdvtpNPGQPAPprpndasqnkTQRQEFQGKTIKSlldqlyrlplsyrhveS 306

                         330       340       350
                  ....*....|....*....|....*....|....
gi 502374592  208 DGFLFDGQNISGVTETGILVRHGKHLHLIHFETL 241
Cdd:TIGR01363 307 DGLIFDPAQITSRTARGVAVPHGDHYHFIPYSQM 340
 
Name Accession Description Interval E-value
strep_his_triad TIGR01363
streptococcal histidine triad protein; This model represents the N-terminal half of a family ...
 1-241 9.04e-11

streptococcal histidine triad protein; This model represents the N-terminal half of a family of Streptococcal proteins that contain a signal peptide and then up to five repeats of a region that includes a His-X-X-His-X-His (histidine triad) motif. Three repeats are found in the seed alignment. Additional copies in more poorly conserved regions may be detected. Members of this family from Streptococcus pneumoniae are suggested to cleave human C3, and the member PhpA has been shown in vaccine studies to be a protective antigen in mice. [Cellular processes, Pathogenesis]


Pssm-ID: 273578 [Multi-domain]  Cd Length: 348  Bit Score: 64.21  E-value: 9.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502374592    1 MKQGKTllYVAGASLICAVALVTYQASNY--REQSNHQKTTSIETSQSKQSKE--IPSD-SKKEvpGIDKatddgflltd 75
Cdd:TIGR01363   1 MKINKK--YLGGSAAILLLSVCSYELGKYqaGSAKEDNRVAYIDGSQAKQKKEnlTPDEvSKRE--GINA---------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502374592   76 ESQIEEKTDLGIIVNHGDHKHFF-------------------------------------------FYSDLK------NT 106
Cdd:TIGR01363  67 EQIVIKITDQGYVTSHGDHYHYYngkvpydaiiseellmkdpnyrlkdsdivneikggyvikvngkYYVYLKdaahadNI 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502374592  107 KWAYLIPENYQEKNHSSQPKRSQ--------LSSGSKQIEDEYVFDPKDIVAEDANGYTVRHGDHYHYILKSSL------ 172
Cdd:TIGR01363 147 RTKEEIARQKQEGSKEAKEKSKRedaavaeaRRQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELsasela 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502374592  173 -------GGTTHRQLTSDSRQ------------SPTLPIV----------HQQEGIPGIDFQT----------------S 207
Cdd:TIGR01363 227 aaeaywsGKQGRGARPSDYRQgsrkasipdvtpNPGQPAPprpndasqnkTQRQEFQGKTIKSlldqlyrlplsyrhveS 306

                         330       340       350
                  ....*....|....*....|....*....|....
gi 502374592  208 DGFLFDGQNISGVTETGILVRHGKHLHLIHFETL 241
Cdd:TIGR01363 307 DGLIFDPAQITSRTARGVAVPHGDHYHFIPYSQM 340
Strep_his_triad pfam04270
Streptococcal histidine triad protein; All members of this family are proteins from ...
 138-172 9.33e-10

Streptococcal histidine triad protein; All members of this family are proteins from Streptococcal species. The proteins are characterized by having a HxxHxH motif that usually occurs multiple times throughout the protein. The histidine triad is predicted to bind metal cations, in particular Zn2+. The zinc is transferred, on the surface of the streptococcus from the Strep_his_triad protein, a zinc scavenger, to apo-ADCAII, a cell-surface lipoprotein transporter that leads to Zn2+ uptake into the bacterium.


Pssm-ID: 461246 [Multi-domain]  Cd Length: 51  Bit Score: 54.66  E-value: 9.33e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 502374592  138 EDEYVFDPKDIVAEDANGYTVRHGDHYHYILKSSL 172
Cdd:pfam04270   3 DDGYIFDPEDIIDDDGDGYITPHGDHFHYIPKDDL 37
 
Name Accession Description Interval E-value
strep_his_triad TIGR01363
streptococcal histidine triad protein; This model represents the N-terminal half of a family ...
 1-241 9.04e-11

streptococcal histidine triad protein; This model represents the N-terminal half of a family of Streptococcal proteins that contain a signal peptide and then up to five repeats of a region that includes a His-X-X-His-X-His (histidine triad) motif. Three repeats are found in the seed alignment. Additional copies in more poorly conserved regions may be detected. Members of this family from Streptococcus pneumoniae are suggested to cleave human C3, and the member PhpA has been shown in vaccine studies to be a protective antigen in mice. [Cellular processes, Pathogenesis]


Pssm-ID: 273578 [Multi-domain]  Cd Length: 348  Bit Score: 64.21  E-value: 9.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502374592    1 MKQGKTllYVAGASLICAVALVTYQASNY--REQSNHQKTTSIETSQSKQSKE--IPSD-SKKEvpGIDKatddgflltd 75
Cdd:TIGR01363   1 MKINKK--YLGGSAAILLLSVCSYELGKYqaGSAKEDNRVAYIDGSQAKQKKEnlTPDEvSKRE--GINA---------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502374592   76 ESQIEEKTDLGIIVNHGDHKHFF-------------------------------------------FYSDLK------NT 106
Cdd:TIGR01363  67 EQIVIKITDQGYVTSHGDHYHYYngkvpydaiiseellmkdpnyrlkdsdivneikggyvikvngkYYVYLKdaahadNI 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502374592  107 KWAYLIPENYQEKNHSSQPKRSQ--------LSSGSKQIEDEYVFDPKDIVAEDANGYTVRHGDHYHYILKSSL------ 172
Cdd:TIGR01363 147 RTKEEIARQKQEGSKEAKEKSKRedaavaeaRRQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELsasela 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 502374592  173 -------GGTTHRQLTSDSRQ------------SPTLPIV----------HQQEGIPGIDFQT----------------S 207
Cdd:TIGR01363 227 aaeaywsGKQGRGARPSDYRQgsrkasipdvtpNPGQPAPprpndasqnkTQRQEFQGKTIKSlldqlyrlplsyrhveS 306

                         330       340       350
                  ....*....|....*....|....*....|....
gi 502374592  208 DGFLFDGQNISGVTETGILVRHGKHLHLIHFETL 241
Cdd:TIGR01363 307 DGLIFDPAQITSRTARGVAVPHGDHYHFIPYSQM 340
Strep_his_triad pfam04270
Streptococcal histidine triad protein; All members of this family are proteins from ...
 138-172 9.33e-10

Streptococcal histidine triad protein; All members of this family are proteins from Streptococcal species. The proteins are characterized by having a HxxHxH motif that usually occurs multiple times throughout the protein. The histidine triad is predicted to bind metal cations, in particular Zn2+. The zinc is transferred, on the surface of the streptococcus from the Strep_his_triad protein, a zinc scavenger, to apo-ADCAII, a cell-surface lipoprotein transporter that leads to Zn2+ uptake into the bacterium.


Pssm-ID: 461246 [Multi-domain]  Cd Length: 51  Bit Score: 54.66  E-value: 9.33e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 502374592  138 EDEYVFDPKDIVAEDANGYTVRHGDHYHYILKSSL 172
Cdd:pfam04270   3 DDGYIFDPEDIIDDDGDGYITPHGDHFHYIPKDDL 37
Strep_his_triad pfam04270
Streptococcal histidine triad protein; All members of this family are proteins from ...
 66-104 3.67e-03

Streptococcal histidine triad protein; All members of this family are proteins from Streptococcal species. The proteins are characterized by having a HxxHxH motif that usually occurs multiple times throughout the protein. The histidine triad is predicted to bind metal cations, in particular Zn2+. The zinc is transferred, on the surface of the streptococcus from the Strep_his_triad protein, a zinc scavenger, to apo-ADCAII, a cell-surface lipoprotein transporter that leads to Zn2+ uptake into the bacterium.


Pssm-ID: 461246 [Multi-domain]  Cd Length: 51  Bit Score: 36.17  E-value: 3.67e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 502374592   66 ATDDGFLLTDESQIEEKTDlGIIVNHGDHKHFFFYSDLK 104
Cdd:pfam04270   1 TTDDGYIFDPEDIIDDDGD-GYITPHGDHFHYIPKDDLS 38
Strep_his_triad pfam04270
Streptococcal histidine triad protein; All members of this family are proteins from ...
 206-242 5.66e-03

Streptococcal histidine triad protein; All members of this family are proteins from Streptococcal species. The proteins are characterized by having a HxxHxH motif that usually occurs multiple times throughout the protein. The histidine triad is predicted to bind metal cations, in particular Zn2+. The zinc is transferred, on the surface of the streptococcus from the Strep_his_triad protein, a zinc scavenger, to apo-ADCAII, a cell-surface lipoprotein transporter that leads to Zn2+ uptake into the bacterium.


Pssm-ID: 461246 [Multi-domain]  Cd Length: 51  Bit Score: 35.79  E-value: 5.66e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 502374592  206 TSDGFLFDGQNISGVTETGILVRHGKHLHLIHFETLK 242
Cdd:pfam04270   2 TDDGYIFDPEDIIDDDGDGYITPHGDHFHYIPKDDLS 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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