The present study was designed to gain insights into the genetic
mechanisms underlying adaptation and diversification by the two most
prevalent pathogenic species of the Burkholderia cepacia complex (Bcc),
B. cenocepacia and B. multivorans. For this, we study the evolution of
both of these species during coinfection of a CF patient for 4.4 years
using genome sequences of 9 B. multivorans and 11 B. cenocepacia. This
co-infection spanned at least 3 years following initial infection by B.
multivorans and ultimately ended in the patient’s death by cepacia
syndrome. This study contributes to the understanding of shared and
species-specific evolutionary patterns of B. cenocepacia and B.
multivorans evolving in the same CF lung environment. The sequences are
deposited herein. This work is the result of a collaboration between
members of the research group of Isabel Sá-Correia: A. Amir Hassan and
Sandra C. dos Santos at the Institute for Bioengineering and Biosciences
(iBB), Instituto Superior Técnico, Universidade de Lisboa, Portugal, and
Vaughn Cooper from the Department of Microbiology and Molecular
Genetics, University of Pittsburgh School of Medicine, USA.
Original Research published in Front. Microbiol. - Evolutionary and Genomic Microbiology, Submitted on: 20 Jun 2020, Edited by: Jianying Gu
Reviewed by: Joanna Goldberg, Jonathan J Dennis
DOI: 10.3389/fmicb.2020.574626
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