U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metagenome-assembled genome: SRR3737021_bin.53_CONCOCT_v1.1_MAG

Identifiers
BioSample: SAMEA14085723; SRA: ERS11688854
Organism
uncultured Clostridia bacterium
cellular organisms; Bacteria; Terrabacteria group; Bacillota; Clostridia; environmental samples
Attributes
collection date2012-08-24
broad-scale environmental contextHost-associated
local-scale environmental contextHuman
environmental mediumDigestive system
geographic locationUSA
investigation typemetagenome-assembled genome
isolation sourcehuman gut metagenome
project nameLive bacteria have been used for decades in an attempt to modulate the human gut microbiota, but their colonization is mostly transient, and a conceptual understanding of the ecological role of exogenous microbes in gut ecosystems is lacking. Here we show that Bifidobacterium longum AH1206 stably persists in the gut of one third of human individuals for at least six months after being orally administered without causing gastrointestinal symptoms or impacting the composition of the resident gut microbiota. Engraftment of AH1206 was associated with low abundance of B. longum and specific carbohydrate utilization genes of this species in the pre-treatment microbiome. This pointed to inter-individual differences in the availability of resources that constitute a niche opportunity for colonization. The findings suggest that bacterial species and functional genes absent in the gut microbiome of individual humans can be reestablished, providing opportunities for precision microbiome reconstitution and a personalization of such strategies.
sample nameSRR3737021_bin.53_CONCOCT_v1.1_MAG
ENA-CHECKLISTERC000047
ENA-FIRST-PUBLIC2023-01-03
ENA-LAST-UPDATE2023-01-03
External IdSAMEA14085723
INSDC center aliasEBI
INSDC center nameEuropean Bioinformatics Institute
INSDC first public2023-01-03T00:33:08Z
INSDC last update2023-01-03T00:33:08Z
INSDC statuspublic
Submitter IdSRR3737021_bin.53_CONCOCT_v1.1_MAG
assembly qualityMany fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly softwaremetaspadesv3.10.0
binning parametersDefault
binning softwareCONCOCT v1.1
broker nameEMG broker account, EMBL-EBI
completeness score89.21
completeness softwareCheckM
contamination score3.57
geographic location (latitude)40.829
geographic location (longitude)-96.667
metagenomic sourcehuman gut metagenome
sample derived fromSAMN05194694
scientific_nameuncultured Clostridia bacterium
sequencing methodIllumina HiSeq 2500
taxonomic identity markermulti-marker approach
Description

This sample represents a Third Party Annotation (TPA) Metagenome-Assembled Genome (MAG) assembled from the metagenomic run SRR3737021 of study SRP076119.

BioProject
PRJEB51075 Large-scale analysis of novel cellular microbes from the human gut biome
Retrieve all samples from this project

Submission
EBI; 2023-01-04
Accession:
SAMEA14085723
ID:
32562349

BioProject Nucleotide

Supplemental Content

Related information

Recent activity

Clear Turn Off Turn On

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
You are here: NCBI > DNA & RNA > BioSample
Support Center