Similar studies for GEO DataSets (Select 200095607) - GEO DataSets

Select item 2000956071.

NtrC-dependent control of exopolysaccharide synthesis and motility in Burkholderia cenocepacia H111

(Submitter supplied) Burkholderia cenocepacia is a versatile opportunistic pathogen that survives in a wide variety of environments, which can be limited in nutrients such as nitrogen. We previously showed that B. cenocepacia sigma factor s54 played a major role in control of nitrogen assimilation and virulence. In this work, we investigated the role of the s54 enhancer binding protein NtrC in controlling the response to nitrogen limitation and virulence. more...

Organism:: Burkholderia cenocepacia H111

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23128
6 Samples

Download data: TXT

Series

Accession:: GSE95607

ID:: 200095607

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000663282.

s54 -dependent response to nitrogen limitation and virulence in Burkholderia cenocepacia H111

(Submitter supplied) Members of the genus Burkholderia are versatile bacteria capable of colonizing highly diverse environmental niches. In this study, we investigated the global response of the opportunistic pathogen Burkholderia cenocepacia H111 to nitrogen limitation at the transcript and protein expression level. In addition to a classical response to nitrogen starvation, including the activation of glutamine synthetase, PII proteins and the two component regulatory system ntrBC, B. more...

Organism:: Burkholderia cenocepacia H111

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16128
5 Samples

Download data: TXT

Series

Accession:: GSE66328

ID:: 200066328

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000485853.

Response of Burkholderia cenocepacia H111 to micro-oxia

(Submitter supplied) B. cenocepacia is an opportunistic human pathogen that is particularly problematic for patients suffering from cystic fibrosis (CF). In the CF lung, bacteria grow to high densities within the viscous mucus that is limited in oxygen. Pseudomonas aeruginosa, the dominant pathogen in CF patients, is known to grow and survive under oxygen-limited to anaerobic conditions by using micro-oxic respiration, denitrification and fermentative pathways. more...

Organism:: Burkholderia cenocepacia H111

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16128
2 Samples

Download data: TXT

Series

Accession:: GSE48585

ID:: 200048585

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000924424.

High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111

(Submitter supplied) In this study, we have analysed the transcriptional profile of B. cenocepacia H111 upon artificially altering the global cellular c-di-GMP levels. A total of 111 genes was found to be differentially expressed, of which 96 genes were down-regulated when c-di-GMP concentrations were increased. The BDSF, AHL and c-di-GMP regulons overlap for the regulation of 24 genes. Intriguingly, at a high intracellular c-di-GMP level expression of the AHL synthase cepI was found to be more than 10-fold down-regulated. more...

Organism:: Burkholderia cenocepacia H111

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16128
8 Samples

Download data: TXT

Series

Accession:: GSE92442

ID:: 200092442

PubMed Similar studies SRA Run Selector

Select item 2000527695.

The IclR-family regulator BapR controls biofilms formation in B. cenocepacia H111

(Submitter supplied) In Burkholderia cenocepacia H111, the large surface protein BapA plays a crucial role in the formation of highly structured communities, known as biofilms. We have recently demonstrated that Quorum sensing (QS) is necessary for the maximal expression of bapA. In this study we identify a protein from the IclR family of transcriptional regulators that, in conjunction with QS, controls biofilm formation by affecting the expression of bapA. more...

Organism:: Burkholderia cenocepacia H111

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16128
2 Samples

Download data: TXT

Series

Accession:: GSE52769

ID:: 200052769

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000971716.

Biosynthesis of the antifungal compound fragin is controlled by a novel quorum sensing signal

(Submitter supplied) Members of the diazeniumdiolate class of natural compounds show great potential for drug development. Yet, their biosynthesis has remained elusive to date. Here, we identify a gene cluster directing the biosynthesis of the diazeniumdiolate compound fragin in Burkholderia cenocepacia H111. We provide evidence that fragin is a metallophore and that metal chelation is the molecular basis of its antifungal activity. more...

Organism:: Burkholderia cenocepacia H111

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23128
9 Samples

Download data: TXT

Series

Accession:: GSE97171

ID:: 200097171

PubMed Full text in PMC Similar studies SRA Run Selector

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