Similar studies for GEO DataSets (Select 200227450) - GEO DataSets

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Items: 3

Select item 2002274501.

Transcriptome of Helicobacter pylori in presence or absence of the cagPAI

(Submitter supplied) To investigate the impact of the cagPAI on transcript regulation of H. pylori, RNA-seq was performed on bacterial samples with presence or absence of the cagPAI.

Organism:: Helicobacter pylori

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19488
4 Samples

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Series

Accession:: GSE227450

ID:: 200227450

PubMed Full text in PMC Similar studies

Select item 2000035562.

Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection.

(Submitter supplied) TC1: gastric epithelial (AGS) cells infected with wild type H. pylori (G27) and isogenic mutants in cagA and vacA for 0, 0.5, 3, 6, and 12 hours. Total RNA was used to make single stranded Cy5 labelled probe and compared to Cy3 labelled probe from uninfected AGS cells. Hybridizations of G27 (trial 4) and cagA- (trial 3) timecourses were done in parallel. A technical replicate of the G27 time course (trial 5) and hybridization of vacA- (trial 3) time course were done in parallel. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

4 related Platforms
54 Samples

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Series

Accession:: GSE3556

ID:: 200003556

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000765893.

Interfering with interferons: cholesterol modification by Helicobacter pylori prevents IFN receptor assembly

(Submitter supplied) Interferons (IFNs) are thought to primarily protect against intracellular pathogens. Here we show that Helicobacter pylori, a chronic colonizer of gastric mucosal surfaces, effectively blocks both type I and type II IFN signalling via cholesterol-α-glucosyltransferase (CaGT). Thus, CaGT, causing depletion of cholesterol from host cells, prevents infected epithelial cells from executing crucial effector functions, including the production of human b-defensin 3 (hBD3). more...