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GEO DataSets

Functional Genomics Studies

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Items: 2

Select item 2002531231.

Targeting Iron - Respiratory Reciprocity Promotes Bacterial Death

(Submitter supplied) Discovering new bacterial signaling pathways offers unique antibiotic strategies. Here, through an unbiased resistance screen of 3,884 gene knockout strains, we uncovered a previously unknown non-lytic bactericidal mechanism that sequentially couples three transporters and downstream transcription to lethally suppress respiration of the highly virulent P. aeruginosa strain PA14 - one of three species on the WHO's 'Priority 1: Critical' list. more...

Organism:: Pseudomonas aeruginosa PA14

Type:: Expression profiling by high throughput sequencing

Platform:: GPL31013
12 Samples

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Accession:: GSE253123

ID:: 200253123

PubMed Full text in PMC Similar studies

Select item 2000653932.

Pseudomonas aeruginosa PA14 differential gene expression in bqsR (PA14_29730) mutants

(Submitter supplied) Before and after anaerobic Fe(II) shocked WT and ∆bqsR of late stationary phase P. aeruginosa PA14 strains Associated publication: Kreamer NN, Costa F, Newman DK. 2015. The ferrous iron-responsive BqsRS two-component system activates genes that promote cationic stress tolerance. mBio 6(1):e02549-14. doi:10.1128/mBio.02549-14.