(Submitter supplied) Bile plays an important role in digestion, absorption of fats, and the excretion of waste products, while concurrently providing a critical barrier against colonization by harmful bacteria. Previous studies have demonstrated that gut pathogens react to bile by adapting their protein synthesis. The ability of pathogens to respond to bile is remarkably complex and still incompletely understood. Here we show that Campylobacter jejuni, a leading bacterial cause of human diarrheal illness worldwide, responds to deoxycholate, a component of bile, by altering global gene transcription in a manner consistent with a strategy to mitigate exposure to reactive oxygen stress.
more...- Organism:
- Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819; Campylobacter jejuni subsp. jejuni F38011; Campylobacter jejuni subsp. jejuni 81-176
- Type:
- Expression profiling by high throughput sequencing
- Platforms:
- GPL22649 GPL22651 GPL22650
- 14 Samples
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