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carB carbamoyl-phosphate synthase large subunit [ Methanothermus fervidus DSM 2088 ]

Gene ID: 9962017, updated on 14-Apr-2023

Summary

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Gene symbol
carB
Gene description
carbamoyl-phosphate synthase large subunit
Locus tag
MFER_RS01535
Gene type
protein coding
Organism
Methanothermus fervidus DSM 2088 (strain: DSM 2088, type-material: type strain of Methanothermus fervidus)
Lineage
Archaea; Euryarchaeota; Methanomada group; Methanobacteria; Methanobacteriales; Methanothermaceae; Methanothermus
Old locus tag
Mfer_0302
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Genomic context

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Sequence:
NC_014658.1 (290009..293209)

NC_014658.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S18-alanine N-acetyltransferase Neighboring gene glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit Neighboring gene roadblock/LC7 domain-containing protein Neighboring gene DUF1611 domain-containing protein Neighboring gene DUF2226 domain-containing protein Neighboring gene cell division protein SepF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_014658.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complete genome sequence of Methanothermus fervidus type strain (V24S). Anderson I, et al. Stand Genomic Sci, 2010 Nov 20. PMID 21304736, Free PMC Article
  2. Selective inactivation of the glutamine binding site of Escherichia coli carbamyl phosphate synthetase by 2-amino-4-oxo-5-chloropentanoic acid. Khedouri E, et al. Biochemistry, 1966 Nov. PMID 5339592
  3. Reversible dissociation of the monomer of glutamine-dependent carbamyl phosphate synthetase into catalytically active heavy and light subunits. Trotta PP, et al. J Biol Chem, 1974 Jan 25. PMID 4358555
  4. Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin. Miles BW, et al. J Biol Chem, 2002 Feb 8. PMID 11729189
  5. Long-range allosteric transitions in carbamoyl phosphate synthetase. Thoden JB, et al. Protein Sci, 2004 Sep. PMID 15322282, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

General protein information

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Preferred Names
carbamoyl-phosphate synthase large subunit
WP_013413383.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_014658.1 Reference assembly

    Range
    290009..293209
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_013413383.1 carbamoyl-phosphate synthase large subunit [Methanothermus fervidus]

    UniProtKB/TrEMBL
    E3GXS3
    Conserved Domains (4) summary
    PRK05294
    Location:1 → 1058
    carB; carbamoyl phosphate synthase large subunit; Reviewed
    cd01424
    Location:930 → 1039
    MGS_CPS_II; Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways ...
    pfam02787
    Location:413 → 532
    CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
    cl17255
    Location:126 → 330
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein
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