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Antimicrobial Susceptibility Testing from US Patent US20240050516: "PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII"
Assay data:32 Active, 32 Activity ≤ 1 µM, 32 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
The drug is tested on Salmonella typhimurium strain: LT2 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Assay data:200 Tested
Summary
The drug is tested on Providencia stuartii strain: ATCC25827 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Assay data:227 Tested
The drug is tested on Providencia rettgeri strain: DSM1131 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Assay data:214 Tested
The drug is tested on Providencia alcalifaciens strain: DSM30120 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Assay data:203 Tested
The drug is tested on Proteus penneri strain: ATCC35198 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Assay data:248 Tested
The drug is tested on Escherichia coli strain: BW25113 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Assay data:205 Tested
The drug is tested on Enterobacter cancerogenus strain: ATCC35316 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
The drug is tested on Edwardsiella tarda strain: ATCC23685 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Genotoxicity in Salmonella typhimurium in absence of metabolic activation by Ames test
Assay data:1 Tested
Genotoxicity in Salmonella typhimurium in presence of metabolic activation by Ames test
Inhibition of CAI-1 mediated quorum-sensing in Vibrio harveyi JMH626 assessed as inhibition of CAI-1 mediated luminescence at 2 uM by bioluminescence assay
Antibacterial activity against Vibrio harveyi infected Anemia franciscana assessed as increase in survival rate at 20 uM and measured after 60 hrs by light microscopy
Inhibition of quorum-sensing system in Vibrio harveyi assessed as inhibition of bioluminescence at 20 uM by bioluminescence assay
Inhibition of biofilm formation in Vibrio harveyi MM77 assessed as inhibition of exopolysaccharides production at 200 uM incubated for 24 hrs by Fluorescence assay
Inhibition of biofilm formation in Vibrio harveyi BB152 at 200 ug/ml for 24 hrs by crystal violet assay
Antimicrobial activity against Vibrio harveyi MM30 assessed as decrease in swimming motility at 200 ug/ml incubated for 15 hrs by agar plate reader analysis
Antimicrobial activity against Vibrio harveyi BB152 assessed as decrease in swimming motility at 200 ug/ml incubated for 15 hrs by agar plate reader analysis
Antimicrobial activity against Vibrio harveyi BB120 assessed as decrease in swimming motility at 200 ug/ml incubated for 15 hrs by agar plate reader analysis
Inhibition of quorum-sensing system in Vibrio harveyi MM77 assessed as inhibition of QS-mediated bioluminescence at 0.02 to 200 uM incubated for 18 hrs by Luminescence assay
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