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Inhibitor Selectivity Assay from Article 10.1021/cb500917m: "Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV."
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
NADs HPLC Enzyme Assay from Article 10.1021/cc9000357: "SAR studies for a new class of antibacterial NAD biosynthesis inhibitors."
Assay data:1 Active, 80 Tested
Fluorescence Resonance Energy Transfer (FRET) Assay from Article 10.1016/j.bmc.2009.08.067: "Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors."
Assay data:22 Active, 7 Activity ≤ 1 µM, 84 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
MAPKKide Assay from Article 10.1111/j.1747-0285.2007.00617.x: "Rhodanine derivatives as selective protease inhibitors against bacterial toxins."
Assay data:39 Active, 3 Activity ≤ 1 µM, 65 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Fluorescence Peptide Cleavage Assay from Article 10.1021/jm8013212: "Thioamide Hydroxypyrothiones Supersede Amide Hydroxypyrothiones in Potency against Anthrax Lethal Factor."
Assay data:6 Active, 28 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Fluorescence Resonance Energy Transfer Assay (FRET) from Article 10.1016/j.bmcl.2006.07.005: "Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease."
Assay data:14 Active, 4 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Enzyme Inhibition Microplate Assay from Article 10.1021/jm0605132: "Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening."
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
HPLC Assay from Article 10.1021/jm0605132: "Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening."
Assay data:18 Active, 3 Activity ≤ 1 µM, 18 Tested
Fluorescence Resonance Energy Transfer Assay (FRET) from Article 10.1016/j.bmcl.2005.12.038: "Guanidinylated 2,5-dideoxystreptamine derivatives as anthrax lethal factor inhibitors."
Assay data:6 Active, 4 Activity ≤ 1 µM, 13 Tested
Fluorescence Resonance Energy Transfer Assay (FRET) from Article 10.1016/j.bmcl.2005.10.088: "The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection."
Assay data:39 Active, 28 Activity ≤ 1 µM, 50 Tested
Fluorescence Peptide Cleavage Assay from Article 10.1021/jm050892j: "Anthrax lethal factor protease inhibitors: synthesis, SAR, and structure-based 3D QSAR studies."
Assay data:10 Active, 16 Tested
Fluorescence Peptide Cleavage Assay from Article 10.1073/pnas.0502733102: "Efficient synthetic inhibitors of anthrax lethal factor."
Assay data:23 Active, 8 Activity ≤ 1 µM, 35 Tested
Binding affinity to Bacillus anthracis lethal factor assessed as inhibition constant
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of Bacillus anthracis lethal factor
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antibacterial activity against Bacillus anthracis
Assay data:2 Tested
SummaryPubMed Citation
Antibacterial activity against Bacillus anthracis 34F2 Sterne assessed as inhibition of bacterial growth incubated upto 3 weeks hrs by resazurin dye based double-dilution method
Assay data:5 Tested
Binding affinity to Bacillus anthracis 2-Epimerase (1 to 371 residues) N370A mutant expressed in Escherichia coli BL21 (DE3)pLysS in presence of UDP-GlcNAc by ligand observed NMR competitive assay
Binding affinity to Bacillus anthracis 2-Epimerase (1 to 371 residues) N370A mutant expressed in Escherichia coli BL21 (DE3)pLysS by isothermal titration calorimetry
Antibacterial activity against Bacillus anthracis Sterne after 12 hrs
Assay data:17 Active, 1 Activity ≤ 1 µM, 26 Tested
Antibacterial activity against Bacillus anthracis Sterne by agar disk diffusion method
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
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