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Activity Assays from US Patent US11471430: "Sphingosine analogs and use thereof against bacterial lung infections"
Assay data:17 Active, 13 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
P. aeruqinosa LpxC Inhibition Assay from US Patent US9718792: "Isoxazoline hydroxamic acid derivatives as LpxC inhibitors"
Assay data:99 Active, 99 Activity ≤ 1 nM, 99 Activity ≤ 1 µM, 99 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Aminoacylation Assay from Article 10.1074/jbc.M114.574061: "The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability."
Assay data:12 Active, 10 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
In Silico Screening from Article 10.1002/cbic.201700052: "Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Thermofluor_Method2 from Article : "Baker-CSAR DIG-BP"
Assay data:4 Active, 2 Activity ≤ 1 µM, 10 Tested
Thermofluor_Method1 from Article : "CSAR LpxC"
Assay data:13 Active, 8 Activity ≤ 1 µM, 32 Tested
Inhibition Assay from US Patent US9290501: "Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase"
Assay data:8 Active, 8 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:7 Active, 5 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Beta-Lactamase Enzyme Inhibition Assay from US Patent US8772490: "Optically active diazabicyclooctane derivatives and process for preparing the same"
Assay data:3 Active, 3 Activity ≤ 1 µM, 4 Tested
PqsA Spectrophotometric Assay from Article 10.1021/acschembio.6b00575: "Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa."
Assay data:5 Active, 5 Activity ≤ 1 µM, 7 Tested
Inhibition Assay from US Patent US9073821: "Hydroxamic acid derivative"
Assay data:37 Active, 37 Activity ≤ 1 µM, 37 Tested
Enzyme Assay from US Patent US8853258: "C-linked hydroxamic acid derivatives useful as antibacterial agents"
Assay data:196 Active, 98 Activity ≤ 1 nM, 196 Activity ≤ 1 µM, 196 Tested
P. aeruginosa MurC assay from Article 10.1021/cb500360c: "Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli."
Assay data:26 Active, 7 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
PvdQ IC50 Assay from Article 10.1021/cb5001586: "Identification of Inhibitors of PvdQ, an Enzyme Involved in the Synthesis of the Siderophore Pyoverdine."
Assay data:48 Active, 33 Activity ≤ 1 µM, 53 Tested
Inhibition Assay from Article 10.1021/bi701954p: "Structure and function of PA4872 from Pseudomonas aeruginosa, a novel class of oxaloacetate decarboxylase from the PEP mutase/isocitrate lyase superfamily."
Assay data:6 Tested
SummaryPubMed Citation
Inhibition Assay from Article 10.1111/j.1747-0285.2007.00608.x: "Selective mapping of chemical space for Pseudomonas aeruginosa deacetylase LpxC inhibitory potential."
Assay data:10 Active, 6 Activity ≤ 1 µM, 18 Tested
β-Lactamase Enzyme Inhibitory Assay from US Patent US9676777: "Compounds useful for producing an optically active diazabicyclooctane compound"
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Antibacterial activity against Pseudomonas aeruginosa HM801 assessed as bacterial growth inhibition incubated overnight by broth microdilution assay
Assay data:5 Tested
Antibacterial activity against Pseudomonas aeruginosa
Induction of drug resistance in Pseudomonas aeruginosa assessed as fold increase in MIC measured after 11 passages
Assay data:1 Tested
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