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Inhibition of Bacillus anthracis anthrax lethal factor using MAPKKide as substrate incubated for 30 mins by fluorescence plate reader analysis
Assay data:2 Active, 2 Tested
SummaryRelated BioAssays by Target
Inhibition of anthrax lethal factor
Assay data:1 Active, 2 Tested
Binding affinity to Bacillus anthracis lethal factor assessed as inhibition constant
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Bacillus anthracis lethal factor
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
MAPKKide Assay from Article 10.1111/j.1747-0285.2007.00617.x: "Rhodanine derivatives as selective protease inhibitors against bacterial toxins."
Assay data:39 Active, 3 Activity ≤ 1 µM, 65 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Fluorescence Peptide Cleavage Assay from Article 10.1021/jm8013212: "Thioamide Hydroxypyrothiones Supersede Amide Hydroxypyrothiones in Potency against Anthrax Lethal Factor."
Assay data:6 Active, 28 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Fluorescence Resonance Energy Transfer Assay (FRET) from Article 10.1016/j.bmcl.2006.07.005: "Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease."
Assay data:14 Active, 4 Activity ≤ 1 µM, 18 Tested
Enzyme Inhibition Microplate Assay from Article 10.1021/jm0605132: "Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening."
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
HPLC Assay from Article 10.1021/jm0605132: "Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening."
Assay data:18 Active, 3 Activity ≤ 1 µM, 18 Tested
Fluorescence Resonance Energy Transfer Assay (FRET) from Article 10.1016/j.bmcl.2005.12.038: "Guanidinylated 2,5-dideoxystreptamine derivatives as anthrax lethal factor inhibitors."
Assay data:6 Active, 4 Activity ≤ 1 µM, 13 Tested
Fluorescence Resonance Energy Transfer Assay (FRET) from Article 10.1016/j.bmcl.2005.10.088: "The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection."
Assay data:39 Active, 28 Activity ≤ 1 µM, 50 Tested
Fluorescence Peptide Cleavage Assay from Article 10.1021/jm050892j: "Anthrax lethal factor protease inhibitors: synthesis, SAR, and structure-based 3D QSAR studies."
Assay data:10 Active, 16 Tested
Fluorescence Peptide Cleavage Assay from Article 10.1073/pnas.0502733102: "Efficient synthetic inhibitors of anthrax lethal factor."
Assay data:23 Active, 8 Activity ≤ 1 µM, 35 Tested
Inhibition of Bacillus anthracis lethal factor protease preincubated for 30 mins prior to addition of substrate containing fluorescent proteins CyPet and YPet measured every 2 mins for 3 hrs in presence of 0.1% BSA by FRET assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 11 Tested
Inhibition of Bacillus anthracis lethal factor protease preincubated for 30 mins prior to addition of substrate containing fluorescent proteins CyPet and YPet measured every 2 mins for 3 hrs by FRET assay relative to control
Assay data:3 Active, 66 Tested
Inhibition of Bacillus anthracis lethal factor protease up to 10 uM preincubated for 30 mins prior to addition of substrate containing fluorescent proteins CyPet and YPet measured every 2 mins for 3 hrs by FRET assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Bacillus anthracis lethal factor protease preincubated for 30 mins prior to addition of substrate containing fluorescent proteins CyPet and YPet measured every 2 mins for 3 hrs by FRET assay
Assay data:17 Active, 13 Activity ≤ 1 µM, 18 Tested
Non-competitive inhibition of Bacillus anthracis lethal factor protease using substrate containing CyPet and YPet linked by RRKKVYPYPMEGTIA sequence preincubated for 30 mins followed by substrate addition measured every 2 mins for 3 hrs by FRET assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 5 Tested
Inhibition of Bacillus anthracis lethal factor protease using substrate containing CyPet and YPet linked by RRKKVYPYPMEGTIA sequence preincubated for 30 mins followed by substrate addition measured every 2 mins for 3 hrs by FRET assay
Inactivation of Bacillus anthracis edema factor in mouse RAW264.7 cells assessed as reduction in cAMP production using cells exposed to edema factor for 30 mins before compound addition for 45 mins by immunoassay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
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