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Thermofluor_Method1 from Article : "CSAR LpxC"
Assay data:13 Active, 8 Activity ≤ 1 µM, 32 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US9073821: "Hydroxamic acid derivative"
Assay data:37 Active, 37 Activity ≤ 1 µM, 37 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Assay from US Patent US8853258: "C-linked hydroxamic acid derivatives useful as antibacterial agents"
Assay data:196 Active, 98 Activity ≤ 1 nM, 196 Activity ≤ 1 µM, 196 Tested
Inhibition Assay from Article 10.1111/j.1747-0285.2007.00608.x: "Selective mapping of chemical space for Pseudomonas aeruginosa deacetylase LpxC inhibitory potential."
Assay data:10 Active, 6 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
P. aeruqinosa LpxC Inhibition Assay from US Patent US9718792: "Isoxazoline hydroxamic acid derivatives as LpxC inhibitors"
Assay data:99 Active, 99 Activity ≤ 1 nM, 99 Activity ≤ 1 µM, 99 Tested
Displacement of fluorescent ligand from Pseudomonas aeruginosa LpxC measured after 30 mins by fluorescence anisotrophy assay
Assay data:21 Active, 1 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 27 Tested
Displacement of (S)-N-(2-(N-(3-biphenyl-4-ylcarboxamido-4-(hydroxyamino)-4-oxobutyl)sulfamoyl)ethyl)-3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxamide fluorescent probe from histidine tagged Pseudomonas aeruginosa LpxC (1-303) expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of fluorscein probe measured after 2 hrs by fluorescence polarization assay
Assay data:11 Active, 7 Activity ≤ 1 µM, 26 Tested
Inhibition of histidine-tagged Pseudomonas aeruginosa LpxC (1-303) expressed in Escherichia coli BL21 (DE3) using UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine as substrate measured after 60 mins by LC-MS/MS analysis
Assay data:6 Active, 3 Activity ≤ 1 µM, 13 Tested
Inhibition of histidine-tagged Pseudomonas aeruginosa LpxC (1-303) expressed in Escherichia coli BL21 (DE3) using UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine as substrate measured after 60 mins by Fluorescence plate reader analysis
Assay data:14 Active, 11 Activity ≤ 1 µM, 25 Tested
Inhibition of LpxC in Pseudomonas aeruginosa assessed as delay in bacterial growth at 25 to 50 ug/ml measured after 20 hrs by CLSI protocol based microbroth dilution method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of LpxC in Pseudomonas aeruginosa assessed as reduction in bacterial growth measured after 20 hrs by CLSI protocol based microbroth dilution method
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to Pseudomonas aeruginosa PAO1 NB52019 LpxC after 60 to 420 secs by SPR method
Assay data:16 Active, 15 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 16 Tested
Inhibition of recombinant Pseudomonas aeruginosa LpxC (1 to 299 residues) C40S mutant expressed in Escherichia coli BL21 AI assessed as change in melting temperature at 25 uM by Sypro orange dye based differential scanning fluorimetry
Assay data:21 Tested
Binding affinity to recombinant Pseudomonas aeruginosa LpxC C40S mutant (1 to 299 residues) expressed in Escherichia coli BL21 AI cells assessed as change in melting temperature at 25 uM SYPRO orange dye based differential scanning fluorimetric method
Assay data:43 Tested
Inhibition of LpxC in Pseudomonas aeruginosa isolate 847
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 7 Tested
Inhibition of LpxC in Pseudomonas aeruginosa isolate 44 ATCC 27853
Assay data:34 Active, 34 Activity ≤ 1 µM, 35 Tested
Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by LC-MS/MS analysis
Assay data:19 Tested
Inhibition of LpxC in Pseudomonas aeruginosa PAO1 assessed as reduction in microbial growth incubated for 22 hrs by MTT assay
Assay data:25 Tested
Inhibition of wild-type Pseudomonas aeruginosa PAO1 LpxC assessed as deacetylation preincubated for 30 mins followed by addition of UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate measured after 60 mins by mass spectrometry
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of wild-type Pseudomonas aeruginosa LpxC preincubated for 20 mins followed by addition of UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate measured after 60 mins by HPLC analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
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