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Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting
Assay data:176 Active, 1 Activity ≤ 1 nM, 87 Activity ≤ 1 µM, 1215 Tested
SummaryRelated BioAssays by Target
Compound was evaluated for inhibition of human PTGS1 in an in vitro cell free assay measured by fluorescence method
Assay data:80 Active, 33 Activity ≤ 1 µM, 924 Tested
Compound was evaluated for inhibition of human PTGS1 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:96 Active, 35 Activity ≤ 1 µM, 927 Tested
Binding affinity towards human HTR2C in an in vitro assay with cellular components measured by radioactivity method
Assay data:123 Active, 1 Activity ≤ 1 nM, 48 Activity ≤ 1 µM, 1199 Tested
Binding affinity towards human CHRM3 in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:93 Active, 1 Activity ≤ 1 nM, 42 Activity ≤ 1 µM, 1188 Tested
Binding affinity towards human ADRA2B in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:166 Active, 1 Activity ≤ 1 nM, 62 Activity ≤ 1 µM, 1209 Tested
In Vitro COX Assay from US Patent US9630914: "Multitarget FAAH and COX inhibitors and therapeutical uses thereof"
Assay data:19 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Cytochrome P450 Family 2 Subfamily C Member 9 (CYP2C9) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2931 Active, 3 Activity ≤ 1 nM, 133 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Antiinflammatory activity against LPS-induced rat Primary neonatal microglia assessed as inhibition in TXB2 generation preincubated for 20 mins followed by PMA-stimulation and measured after 70 mins by immunoassay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of catalytic activity of His6-tagged Lactobacillus johnsonii N6.2 cinnamoyl esterase LJ0536 expressed in Escherichia coli BL21 (DE3) assessed as reduction in hydrolysis of 4-nitrophenyl butyrate in 4-nitrophenol at 400 uM in presence of 2.5 to 20 mM enzyme pre-incubated for 2 hrs
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells
Assay data:827 Active, 4426 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells
Assay data:805 Active, 4425 Tested
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells
Assay data:1111 Active, 4426 Tested
Diffuse intrinsic pontine glioma (SU-DIPG-XIII) cell line screen of MIPE4.0 library: viability qHTS assay using CellTiter-Glo
Assay data:325 Active, 1912 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
Inhibition of COX-2 (unknown origin)
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of COX-1 (unknown origin)
Rat ASIC1 (Acid-sensing (proton-gated) ion channels (ASICs))
Assay data:2 Active, 2 Tested
Human COX-1 (Cyclooxygenase)
Assay data:27 Active, 27 Tested
Human COX-2 (Cyclooxygenase)
Assay data:34 Active, 34 Tested
Inhibition of recombinant human COX2 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic acid as substrate by enzyme immunoassay
Assay data:15 Active, 11 Activity ≤ 1 µM, 40 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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