Protein Family Models for Gene (Select 49393071) - Protein Family Models

Select item 2579551.

preprotein translocase subunit SecA is part of the Sec protein translocase complex, playing a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor

Date:: 2019-08-21

Family Accession:: 11486333
Method:: Sparcle

Select item 1678742.

preprotein translocase subunit SecA

Functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimer

Gene:: secA

Date:: 2020-10-26

Family Accession:: NF006630.0
Method:: HMM

Select item 1298143.

new record, indexing in progress

Family Accession:

Select item 1298134.

new record, indexing in progress

Family Accession:

Select item 1291265.

new record, indexing in progress

Family Accession:

Select item 1291256.

new record, indexing in progress

Family Accession:

Select item 307047.

preprotein translocase subunit SecA

Gene:: secA

GO Terms:

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: protein targeting (GO:0006605)

Biological Process:: intracellular protein transport (GO:0006886)

Biological Process:: protein import (GO:0017038)

Date:: 2021-07-21

Family Accession:: NF009538.1
Method:: HMM

Select item 280058.

new record, indexing in progress

Family Accession:

Select item 276869.

new record, indexing in progress

Family Accession:

Select item 2484110.

preprotein translocase subunit SecA

The proteins SecA-F and SecY, not all of which are necessary, comprise the standard prokaryotic protein translocation apparatus. Other, specialized translocation systems also exist but are not as broadly distributed. This HMM describes SecA, an essential member of the apparatus. This model excludes SecA2 of the accessory secretory system.

Gene:: secA

GO Terms:

Cellular Component:: cytoplasmic side of plasma membrane (GO:0009898)

Molecular Function:: protein-transporting ATPase activity (GO:0015450)

Molecular Function:: ATP hydrolysis activity (GO:0016887)

Biological Process:: protein transport by the Sec complex (GO:0043952)

Date:: 2021-04-27

Family Accession:: TIGR00963.1
Method:: HMM

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