Protein Family Models

This putative domain is found at the N-terminus of a large number of bacterial proteins. Its adhesive function was described in Lactobacillus reuteri serine-rich repeat proteins [1]. Structure predictions show it is composed of a beta solenoid repeat related to Pectate lyase. [1]. 29507249. Structural basis for the role of serine-rich repeat proteins. from Lactobacillus reuteri in gut microbe-host interactions.. Sequeira S, Kavanaugh D, MacKenzie DA, Suligoj T, Walpole S,. Leclaire C, Gunning AP, Latousakis D, Willats WGT, Angulo J,. Dong C, Juge N;. Proc Natl Acad Sci U S A. 2018;115:E2706. (from Pfam)

Date:

2024-04-03

This entry represents the Long Rib domain that is closely related to the Pfam:PF08428 Rib domain but has a conserved insertion. These domains are found in bacterial cell surface proteins. (from Pfam)

Date:

2023-12-12

This domain of bacterial surface proteins, about 80 amino acids long and often repeated 15 times or more in a protein sequence, is named for early described proteins such as Rib and alpha, but found in proteins with a wide variety of architectures and from various lineages.

Date:

2024-04-03

Date:

2023-12-12

The YPDG domain may occur once in a protein, or up to 22 times in tandem repeats. It is common in proteins of Gram-positive bacteria with C-terminal LPXTG sites for anchoring on the cell surface.

Date:

2020-10-26

This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region.

Date:

2021-04-27

Sequences in this family are tandem repeats of about 79 amino acids, present in up to 14 copies in a protein and highly identical, even at the DNA level, within each protein. Sequences with these repeats are found in the Rib and alpha surface antigens of group B Streptococcus, Esp of Enterococcus faecalis, and related proteins of Lactobacillus. The repeat lacks Cys residues. Most members of this protein family also have the cell wall anchor motif LPXTG shared by many staphyloccal and streptococcal surface antigens.

Date:

2021-07-14