Protein Family Models for Protein (Select 491032832) - Protein Family Models

Select item 4092181.

site-specific tyrosine recombinase/integron integrase

Proteins of this family are site-specific tyrosine recombinases in Archaea. The recent study (PMID: 36383678) reported that they were the key components of archaeal integrons and were involved in cross-domain gene transfer.

Gene:: xerA

GO Terms:

Biological Process:: DNA transposition (GO:0006313)

Molecular Function:: integrase activity (GO:0008907)

Molecular Function:: tyrosine-based site-specific recombinase activity (GO:0009037)

Date:: 2023-11-21

Family Accession:: NF040815.2
Method:: HMM

Select item 4022772.

phage integrase N-terminal SAM-like domain-containing protein

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Biological Process:: DNA integration (GO:0015074)

Date:: 2023-12-12

Family Accession:: NF024886.4
Method:: HMM

Select item 3891503.

tyrosine-type recombinase/integrase

Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase (Swiss:P06956) are Arg-173, His-289, Arg-292 and Tyr-324. [1]. 9082984. Flexibility in DNA recombination: structure of the lambda. integrase catalytic core.. Kwon HJ, Tirumalai R, Landy A, Ellenberger T;. Science 1997;276:126-131.. [2]. 9288963. Structure of Cre recombinase complexed with DNA in a. site-specific recombination synapse.. Guo F, Gopaul DN, van Duyne GD;. Nature 1997;389:40-46. (from Pfam)

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Biological Process:: DNA recombination (GO:0006310)

Biological Process:: DNA integration (GO:0015074)

Date:: 2024-04-03

Family Accession:: NF012798.4
Method:: HMM

Select item 3572664.