Abstract
Conserved pairs of CBS sequence motifs (named after cystathionine beta-synthase) found in a wide variety of proteins associate to form Bateman domains. A new study establishes that Bateman domains bind adenosyl compounds and regulate IMP dehydrogenase, CBS, chloride channels, and AMP-activated protein kinase. This discovery reveals how mutations in CBS sequences in these proteins cause hereditary diseases and provides a rich vista of conceptual opportunities for therapies in energy metabolism, obesity, diabetes, cancer, antivirals, and immunosuppression.
Publication types
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Research Support, Non-U.S. Gov't
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Review
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Comment
MeSH terms
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AMP-Activated Protein Kinases
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Adenosine Monophosphate / chemistry
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Adenosine Triphosphate / chemistry*
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Amino Acid Motifs
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Animals
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Chlorine / chemistry
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Cystathionine beta-Synthase / chemistry*
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Humans
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IMP Dehydrogenase / chemistry*
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Immunosuppressive Agents / pharmacology
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Models, Molecular
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Multienzyme Complexes / chemistry
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Mutation
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Protein Binding
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Protein Serine-Threonine Kinases / chemistry
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Protein Structure, Tertiary
Substances
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Immunosuppressive Agents
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Multienzyme Complexes
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Adenosine Monophosphate
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Chlorine
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Adenosine Triphosphate
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IMP Dehydrogenase
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Protein Serine-Threonine Kinases
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AMP-Activated Protein Kinases
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Cystathionine beta-Synthase