Abstract
We have identified and sequenced the genes encoding the quinolone-resistance determining region (QRDR) of ParC and GyrA in fluoroquinolone-susceptible and -resistant Streptococcus suis clinical isolates. Resistance is the consequence of single point mutations in the QRDRs of ParC and GyrA and is not due to clonal spread of resistant strains or horizontal gene transfer with other bacteria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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DNA Gyrase / genetics
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DNA Topoisomerase IV / genetics
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Drug Resistance, Bacterial* / genetics
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Female
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Fluoroquinolones / pharmacology*
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Genes, Bacterial
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Humans
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Male
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Molecular Sequence Data
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Point Mutation
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RNA, Ribosomal, 16S / genetics
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Sequence Alignment
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Streptococcus suis* / drug effects
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Streptococcus suis* / genetics
Substances
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Fluoroquinolones
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RNA, Ribosomal, 16S
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DNA Topoisomerase IV
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DNA Gyrase
Associated data
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GENBANK/DQ832724
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GENBANK/DQ832725
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GENBANK/DQ832726
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GENBANK/DQ832727
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GENBANK/DQ832728
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GENBANK/DQ832729
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GENBANK/DQ832730
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GENBANK/DQ832731
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GENBANK/DQ832732
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GENBANK/DQ832733
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GENBANK/DQ832734
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GENBANK/DQ832735
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GENBANK/DQ832736
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GENBANK/DQ832737
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GENBANK/DQ832738
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GENBANK/DQ832739
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GENBANK/DQ832740
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GENBANK/DQ832741
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GENBANK/DQ832742
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GENBANK/DQ832743
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GENBANK/DQ832744
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GENBANK/DQ832745
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GENBANK/DQ832746
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GENBANK/DQ832747
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GENBANK/DQ832748
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GENBANK/DQ832749
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GENBANK/DQ832750
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GENBANK/DQ832751
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GENBANK/DQ832752
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GENBANK/DQ832753
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GENBANK/DQ832754
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GENBANK/DQ832755
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GENBANK/DQ832756
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GENBANK/DQ832757
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GENBANK/DQ832758
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GENBANK/DQ832759