Abstract
A series of methylated imidazolium salts with varying substituents on the 4 and 5 positions of the imidazole ring were synthesized. These salts were reacted with silver acetate to afford their corresponding silver N-heterocyclic carbene (NHC) complexes. These complexes were then evaluated for their stability in water as well as for their antimicrobial efficacy against a variety of bacterial strains associated with cystic fibrosis and chronic lung infections.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acetates / chemistry*
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Burkholderia / drug effects*
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Burkholderia / growth & development
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Electrons
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Escherichia coli / drug effects*
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Escherichia coli / growth & development
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Heterocyclic Compounds / chemistry
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Methane / analogs & derivatives
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Methane / chemistry
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Methylation
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Microbial Sensitivity Tests
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Models, Molecular
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Molecular Structure
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Organometallic Compounds* / chemical synthesis
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Organometallic Compounds* / chemistry
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Organometallic Compounds* / pharmacology
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / growth & development
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Silver Compounds / chemistry*
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Structure-Activity Relationship
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Water / chemistry
Substances
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Acetates
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Anti-Bacterial Agents
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Heterocyclic Compounds
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Organometallic Compounds
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Silver Compounds
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Water
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silver acetate
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carbene
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Methane