Abstract
The in vitro activities of ceftaroline, a novel, parenteral, broad-spectrum cephalosporin, and four comparator antimicrobials were determined against anaerobic bacteria. Against Gram-positive strains, the activity of ceftaroline was similar to that of amoxicillin-clavulanate and four to eight times greater than that of ceftriaxone. Against Gram-negative organisms, ceftaroline showed good activity against beta-lactamase-negative strains but not against the members of the Bacteroides fragilis group. Ceftaroline showed potent activity against a broad spectrum of anaerobes encountered in respiratory, skin, and soft tissue infections.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amoxicillin-Potassium Clavulanate Combination / pharmacology
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Anti-Bacterial Agents / pharmacology*
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Bacteria, Anaerobic / drug effects*
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Bacteria, Anaerobic / pathogenicity
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Bacterial Infections / drug therapy
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Bacterial Infections / microbiology
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Bacteroides fragilis / drug effects
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Ceftaroline
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Ceftriaxone / pharmacology
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Cephalosporins / pharmacology*
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Drug Resistance, Bacterial
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Gram-Negative Aerobic Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Humans
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In Vitro Techniques
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Microbial Sensitivity Tests
Substances
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Anti-Bacterial Agents
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Cephalosporins
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Amoxicillin-Potassium Clavulanate Combination
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Ceftriaxone