GEO DataSets

(Submitter supplied) Pathogenic microorganisms have evolved various strategies to sense and respond to stress in order to establish infection and ensure survival within the host's complex environment. Hypoxia, a metabolic stress factor encountered by aerobic microorganisms during rapid growth, remains poorly understood in terms of pathogen adaptation. Streptococcus suis, a zoonotic pathogen causing meningitis and sepsis, exhibits remarkable adaptability to anaerobic conditions. more...

Organism:

Streptococcus suis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28677

6 Samples

Download data: TXT

(Submitter supplied) To investigate the gene transcription profiles of Streptococcus suis in the planktonic state and biofilm state, we provided samples cultured for 8 h in the planktonic state and samples cultured for 24 h in vitro biofilm. We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 different samples at two time points.

Organism:

Streptococcus suis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30562

4 Samples

Download data: XLS

(Submitter supplied) Streptococcus suis is a major pig pathogen as well as an emerging zoonotic pathogen. We studied the generic and adaptive resistance response of S. suis upon exposure to sub-lethal concentrations of the human cathelicidin LL-37. We aimed to search for inducible mechanisms of resistance to AMPs as well as induction of virulence gene expression upon exposure to AMPs, in order to gain insights into host-derived factors that might mediate S. more...

Organism:

Streptococcus suis

Type:

Expression profiling by array

Platform:

GPL22805

8 Samples

Download data: TXT, XLSX

(Submitter supplied) RNA sequencing analysis of the transcriptome of the wild type (WT) strain and ΔadcR mutant. The data revealed that genes encoding the Zn acquisition systems were negatively regulated by AdcR.

Organism:

Streptococcus suis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30562

6 Samples

Download data: XLS

(Submitter supplied) Pathogenic bacteria encounter a variety of stressful host environments during infection. Their responses to meet these challenges protect them from deadly damages and aid in adaption to harmful environments. Bacterial products critical for this protection are therefore interesting as suitable targets for new antimicrobials. To shed light on the complex array of molecular pathways involved in bacterial stress responses we challenged 32 diverse human pathogenic bacteria to 11 infection related stress conditions and catalogued their transcriptomes. more...

Organism:

Borreliella burgdorferi; Pseudomonas aeruginosa; Legionella pneumophila; Klebsiella pneumoniae; Yersinia pseudotuberculosis; Vibrio cholerae; Streptococcus suis; Streptococcus agalactiae; Streptococcus pneumoniae; Mycobacterium tuberculosis; Burkholderia pseudomallei; Neisseria meningitidis; Staphylococcus epidermidis; Streptococcus pyogenes; Listeria monocytogenes; Salmonella enterica; Achromobacter xylosoxidans; Campylobacter jejuni; Francisella tularensis; Acinetobacter baumannii; Neisseria gonorrhoeae; Escherichia coli; Shigella flexneri; Aggregatibacter actinomycetemcomitans; Haemophilus influenzae; Staphylococcus aureus subsp. aureus MRSA252; Staphylococcus aureus subsp. aureus MSSA476; Helicobacter pylori; Enterococcus faecalis

Type:

Expression profiling by high throughput sequencing

30 related Platforms

1122 Samples

Download data: TXT

(Submitter supplied) The transcriptome of the wild type strain and ΔtroR of Streptococcus suis was compared by RNA sequencing analysis. The data revealed that some genes, such as the troABCD operon, were significantly differentially expressed in the ΔtroR mutant.

Organism:

Streptococcus suis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28813

6 Samples

Download data: TXT

(Submitter supplied) We explored the transcriptome change of Streptococcus suis in the presence of manganese by RNA sequencing. The data revealed that the genes in the troABCD operon were significantly downregulated in response to manganese.

Organism:

Streptococcus suis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28813

6 Samples

Download data: XLSX

(Submitter supplied) We explored the transcriptome change of Streptococcus suis in the presence of ferrous iron and cobalt by RNA sequencing. The data revealed that expression of a lot of genes was altered to respond to ferrous iron and cobalt toxicity. Moreover, most of the genes differentially expressed in response to cobalt are the same as those in response to ferrous iron.

Organism:

Streptococcus suis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28813

9 Samples

Download data: XLSX

(Submitter supplied) Two large-scale outbreaks of streptococcal toxic shock-like syndrome (STSLS) have revealed Streptococcus suis 2 (SS2) to be a severe, evolving pathogen in humans. We investigated the mechanism by which SS2 causes STSLS. The transcriptional regulator TstS up-regulated during experimental infection. Compared with the wild type 05ZY strain, the tstS deletion mutant (∆tstS) elicited reduced cytokine secretion in macrophages. more...

Organism:

Streptococcus suis

Type:

Expression profiling by array

Platform:

GPL20080

8 Samples

Download data: TXT

(Submitter supplied) To reveal the scope of the stk regulation and explore the differences in the regulatory roles of SC-19 and ∆stk, the global gene transcription profiles of the WT and ∆stk strains were determined by RNA-seq analysis.

Organism:

Streptococcus suis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22539

2 Samples

Download data: TXT

(Submitter supplied) Streptococcus suis is a major pig pathogen as well as an emerging zoonotic pathogen. In a previous study (Zaccaria et al. Plos One DOI: 10.1371/journal.pone.0099394) we identified the natural pheromone-induced competence system of S. suis. To identify the mechanisms enabling competence, gene expression analysis of bacteria induced or not for competence, and in presence or absence of exogenous DNA, was assessed at 5, 15 and 45 minutes after pheromone addition. more...

Organism:

Streptococcus suis

Type:

Expression profiling by array

Platform:

GPL16024

16 Samples

Download data: TXT, XLSX

(Submitter supplied) The interactions of Streptocococcus suis (S.suis) with human microvascular endothelial cells (hBMEC) are important process for S.suis passage across human blood brain barrier (BBB). S.suis has evolved precise mechanisms to alter gene expression depending on the distinct challenges posed by particular disease sites. Herein, a whole-genome DNA microarray was used to investigate the change of gene expression profile of S.suis after contact with hBMEC 3 h. more...

Organism:

Streptococcus suis 05ZYH33

Type:

Expression profiling by array

Platform:

GPL9675

4 Samples

Download data: GPR

(Submitter supplied) The interactions of Streptocococcus suis (S.suis) with human microvascular endothelial cells (hBMEC) are important process for S.suis passage across human blood brain barrier (BBB). S.suis has evolved precise mechanisms to alter gene expression depending on the distinct challenges posed by particular disease sites. Herein, a whole-genome DNA microarray was used to investigate the change of gene expression profile of S.suis after contact with hBMEC 1 h. more...

Organism:

Streptococcus suis 05ZYH33

Type:

Expression profiling by array

Platform:

GPL9675

4 Samples

Download data: GPR

(Submitter supplied) Growth curves and (p)ppGpp accumulation assays showed that RelA inactivation could influence S. suis growth and led to incapacity of (p)ppGpp synthesis during glucose starvation. To identify the roles of RelA/(p)ppGpp in global gene regulation in S. suis, we compared the transcriptional profiles of SC-19 [a (p)ppGpp+ strain] and ΔrelA [a (p)ppGpp0 strain during glucose starvation] in both glucose-abundant and -deficient CDM in exponential phase by microarray analysis. more...

Organism:

Streptococcus suis

Type:

Expression profiling by array

Platform:

GPL20080

12 Samples

Download data: TXT

(Submitter supplied) During infection in the air pouches, S. suis encounters changing environments and host factors. It is important for S. suis to modulate the gene expression in response to stimulants. Using DNA microarray analysis, we compared the transcriptome of S. suis obtained from the air pouches with that from working cultures.

Organism:

Streptococcus suis; Streptococcus suis SC84

Type:

Expression profiling by array

Platform:

GPL18421

8 Samples

Download data: TXT

(Submitter supplied) To investigate the effect of CodY mutation on the gene expression in Streptococcus suis serotype 2 SC19 strain, we have employed whole genome microarray expression profiling as a discovery platform to identify genes regulated by CodY mutation. DNA microarray analysis was performed using an Agilent custom-designed oligonucleotide microarray. Based upon the whole genome sequence of SC19 , specific 60-mer oligonucleotide probes were designed using eArray (https://earray.chem.agilent.com/earray/), to cover all annotated genes. more...

Organism:

Streptococcus suis

Type:

Expression profiling by array

Platform:

GPL20080

2 Samples

Download data: TXT

(Submitter supplied) To reveal the scope of the Spx regulation and explore the differences in the regulatory roles of SpxA1 and SpxA2, the global gene transcription profiles of the WT, ∆spxA1 and ∆spxA2 strains were determined by DNA microarray analysis performed using an Agilent custom-designed oligonucleotide microarray.

Organism:

Streptococcus suis SC84; Streptococcus suis

Type:

Expression profiling by array

Platform:

GPL18421

8 Samples

Download data: TXT

(Submitter supplied) Streptococcus suis is an important zoonotic pathogen that can cause meningitis and sepsis in both pigs and humans. In this study,we evaluated the genetic difference of 40 Streptococcus suis strains belonging to various sequence types by comparative genomic hybridization to identify genes associated with the variation in pathogenicity using NimbleGen’s tilling microarray platform. Application of Comparative Phylogenomics to Identify Genetic Differences Relating to Pathogenicity of Streptococcus suis

Organism:

Streptococcus suis

Type:

Genome variation profiling by genome tiling array

Platforms:

GPL15923 GPL15924

80 Samples

Download data: PAIR, TXT

(Submitter supplied) Streptococcus suis is a major pig pathogen as well as an emerging zoonotic pathogen. Previous work has demonstrated that the S. suis extracellular amylopullulanase enzyme (ApuA) that degrades {alpha}-glucans also functions as an adhesin for porcine epithelial cells. To identify the mechanisms linking carbohydrate metabolism and virulence, we first compared the transcriptome of S. suis in minimal medium supplemented with glucose to minimal medium containing a complex carbohydrate pullulan as a carbon source. more...

Organism:

Streptococcus suis; Streptococcus suis P1/7

Type:

Expression profiling by array

Platform:

GPL16024

16 Samples

Download data: TXT

(Submitter supplied) Streptococcus suis is an important emerging worldwide pig pathogen and zoonotic agent with rapid evolution of virulence and drug resistance. Licochalcone A, used in traditional Chinese medicine, exhibits antimicrobial, antioxidant and anti-inflammatory activities. Herein, a whole-genome DNA microarray was used to investigate the global transcriptional regulation of Streptococcus suis 05ZYH33 treated by subinhibitory concentration of licochalcone A. more...

Organism:

Streptococcus suis 05ZYH33

Type:

Expression profiling by array

Platform:

GPL9675

4 Samples

Download data: GPR