GEO DataSets

(Submitter supplied) In this study we focused on understanding the effect of over expression of recombinant protective antigen (rPA) on the Bacillus anthracis metabolism and genes expression with the purpose of improving the production of this recombinant toxin in particular and recombinant proteins in general. To achieve this goal controlled growth of the B. anthracis ames strain transformed with pYS5 (PA producer) plasmid encoding protective antigen and the corresponding empty vector pSW4 (non-producer) were performed and protein production, bacterial growth characteristics and gene transcription pattern were analyzed. more...

Organism:

Bacillus anthracis str. Ames

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24488

18 Samples

Download data: TXT

(Submitter supplied) Edema factor of anthrax binds to the protective antigen (PA83) which cleaves to PA63 and PA20. The role of PA20 was examined using highthroughput gene expression analysis of human peripheral blood mononuclear cells (PBMC) exposed to PA20. Keywords: Toxicity determination

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3033

14 Samples

Download data: GPR

(Submitter supplied) Using RNA-seq, we report here that CodY regulation is hierarchically regulated in response to environmental starvation.

Organism:

Bacillus anthracis str. Sterne

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20947

24 Samples

Download data: TXT

(Submitter supplied) The High Temperature Requirement (HtrA) chaperone/protease is involved in the stress-response of the anthrax-causing pathogen Bacillus anthracis. Resilience to oxidative stress is essential for manifestation of B. anthracis pathogenicity. We submitt transcriptome data sets detailing global gene expression in B. anthracis wild-type and htrA-disrupted strains following H2O2-induced oxidative stress.

Organism:

Bacillus anthracis str. Vollum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28578

14 Samples

Download data: TXT